Lupus nephritis
MONDO:0005556Glomerulonephritis in the context of systemic lupus erythematosus.
Also known as: SLE nephritis, lupus glomerulonephritis, lupus nephritis, Glomerulonephritides, lupus, Nephritides, lupus, glomerulonephritis, lupus, lupus Glomerulonephritides, lupus Nephritides
142 clinical trials for this condition and its sub-types, 140 tagged with Lupus nephritis itself.
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Could CAR-T cells tame tough lupus kidney disease?
Disease control Stopped earlyThis early-phase trial is testing a new treatment called KYV-101, which uses a patient's own modified immune cells (CAR-T cells) to target and destroy faulty B cells that drive lupus kidney inflammation. The study involves 6 adults with lupus nephritis that hasn't responded to st…
Phase 1/2 • Sponsor: Kyverna Therapeutics • Aim: Disease control
Last updated Sep 02, 2026 00:00 UTC
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Experimental CAR-T therapy takes on Hard-to-Treat lupus nephritis
Disease control Stopped earlyThis early-phase trial is testing a personalized cell therapy called KYV-101 for people with lupus nephritis that hasn't responded to standard treatments. The therapy uses a patient's own immune cells, modified to target and destroy faulty B cells that drive the disease. Only 2 p…
Phase 1/2 • Sponsor: Kyverna Therapeutics • Aim: Disease control
Last updated Sep 02, 2026 00:00 UTC
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New drug OMS721 tested for rare kidney conditions
Disease control Stopped earlyThis study tested a drug called OMS721 in 31 people with certain kidney diseases, including IgA nephropathy and lupus nephritis. The main goal was to check if the drug is safe and if it reduces protein in the urine, a sign of kidney damage. The study was stopped early, so results…
Phase 2 • Sponsor: Omeros Corporation • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
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Lupus kidney drug for teens shows promise, but trial cut short
Disease control Stopped earlyThis study tested a drug called voclosporin in teenagers with lupus nephritis, a kidney disease caused by lupus. The goal was to see if it could improve kidney function better than a placebo. Only 9 teens took part before the study was stopped early, so we don't have clear answer…
Phase 3 • Sponsor: Aurinia Pharmaceuticals Inc. • Aim: Disease control
Last updated Jun 27, 2026 09:03 UTC
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Lupus kidney drug tested in kids – but study stopped early
Disease control Stopped earlyThis study looked at the long-term safety of the drug voclosporin in adolescents and children with lupus nephritis, a kidney disease caused by lupus. Participants took voclosporin capsules twice daily along with standard medications. The trial was terminated early and only enroll…
Phase 3 • Sponsor: Aurinia Pharmaceuticals Inc. • Aim: Disease control
Last updated Jun 27, 2026 09:03 UTC
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Experimental drug ravulizumab tested for kidney inflammation
Disease control Stopped earlyThis Phase 2 study tested the drug ravulizumab (Ultomiris) in 123 adults with lupus nephritis or IgA nephropathy, two conditions that cause kidney inflammation. Participants received either ravulizumab or a placebo alongside standard care. The study aimed to see if the drug could…
Phase 2 • Sponsor: Alexion Pharmaceuticals, Inc. • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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Lupus kidney drug trial halted midway
Disease control Stopped earlyThis study tested a drug called zetomipzomib for people with active lupus nephritis, a kidney disease caused by lupus. The goal was to see if the drug could improve kidney function better than a placebo over 52 weeks. The trial was terminated early, so results are limited. Partic…
Phase 2 • Sponsor: Kezar Life Sciences, Inc. • Aim: Disease control
Last updated Jun 27, 2026 08:02 UTC
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Kidney disease drug trial halted midway: what happened?
Disease control Stopped earlyThis study tested a drug called ALXN2050 in people with kidney inflammation caused by lupus (lupus nephritis) or IgA nephropathy. The goal was to see if it could reduce protein in the urine, a sign of kidney damage. About 100 adults were planned to take the drug or a placebo alon…
Phase 2 • Sponsor: Alexion Pharmaceuticals, Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC