Long QT syndrome
MONDO:0002442A condition that is characterized by episodes of fainting (syncope) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are Romano-Ward syndrome (also known as long QT syndrome 1) and Jervell-Lange Nielsen syndrome.
Also known as: long QT syndrome, ventricular arrhythmia associated with long QT syndrome
29 clinical trials for this condition and its sub-types, 22 tagged with Long QT syndrome itself.
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Sub-types of Long QT syndrome
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Familial long QT syndrome 1 trial · 11 incl. sub-types
19 sub-types
- Long QT syndrome 3 5 trials
- Long QT syndrome 2 3 trials
- Jervell and Lange-Nielsen syndrome 2 trials Sub-types →
- Timothy syndrome 1 trial Sub-types →
- Long QT syndrome 1 1 trial
- Long QT syndrome 5 0 trials · 1 incl. sub-types Sub-types →
- Andersen-Tawil syndrome 0 trials
- Cardiac arrhythmia, ankyrin-B-related 0 trials
- Long QT syndrome 10 0 trials
- Long QT syndrome 11 0 trials
- Long QT syndrome 12 0 trials
- Long QT syndrome 13 0 trials
- Long QT syndrome 14 0 trials
- Long QT syndrome 15 0 trials
- Long QT syndrome 16 0 trials
- Long QT syndrome 4 0 trials
- Long QT syndrome 6 0 trials
- Long QT syndrome 8 0 trials
- Long QT syndrome 9 0 trials
Most studied deeper sub-types
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Single-Patient trial tests heart drug for rare genetic syndrome
Symptom relief CompletedThis study tested whether a single intravenous dose of diltiazem, a calcium channel blocker, can shorten the QT interval in adults with Jervell and Lange-Nielsen syndrome, a rare genetic heart condition that increases the risk of dangerous heart rhythms. Only one person participa…
Phase 4 • Sponsor: Vanderbilt University Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 07:54 UTC
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Can a treadmill test predict a Child's heart rate at play?
Knowledge-focused CompletedThis study looks at children and adolescents aged 6 to 16 with inherited arrhythmias, such as long QT syndrome, to see if a controlled exercise test on a treadmill reflects their actual heart rate and activity levels during daily life. Participants will complete a routine exercis…
Sponsor: Royal Brompton & Harefield NHS Foundation Trust • Aim: Knowledge-focused
Last updated Sep 03, 2026 00:00 UTC
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Can hormones during pregnancy reshape the Heart's electrical beat?
Knowledge-focused CompletedThis study tracks heart rhythm changes in women from late pregnancy to after delivery, comparing healthy women and those with congenital long QT syndrome, a condition that affects the heart's electrical activity. Researchers use ECGs and blood tests to measure how sex hormones li…
Sponsor: French Cardiology Society • Aim: Knowledge-focused
Last updated Aug 21, 2026 00:00 UTC
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Hidden nerve damage may disrupt Heart's electrical activity during surgery
Knowledge-focused CompletedThis study looks at whether cardiac autonomic neuropathy (nerve damage that affects heart rate control) changes the heart's electrical recovery time (QT interval) in people having coronary artery bypass surgery. Researchers will test nerve function before surgery and measure hear…
Sponsor: Haseki Training and Research Hospital • Aim: Knowledge-focused
Last updated Jul 08, 2026 00:00 UTC
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Heart conditions in kids: study reveals impact on daily life and play
Knowledge-focused CompletedThis study looks at how inherited heart rhythm problems (like Long QT Syndrome) and heart muscle diseases (like Hypertrophic Cardiomyopathy) affect the quality of life and physical activity of children aged 6 to 18. Researchers will compare 107 children with these conditions to 1…
Sponsor: University Hospital, Montpellier • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Hormone shield: could progesterone or testosterone guard against Drug-Induced heart risks?
Knowledge-focused CompletedThis study looked at whether taking progesterone (in women) or testosterone (in men) could reduce dangerous changes in heart rhythm caused by certain medications. 73 healthy older adults (postmenopausal women and men 65+) took either the hormone or a placebo, then received a smal…
Phase 4 • Sponsor: Indiana University • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC