Locked-in syndrome

MONDO:0016567

Locked-in syndrome (LIS) is a neurological condition characterized by the presence of sustained eye opening, quadriplegia or quadriparesis, anarthria, preserved cognitive functioning and a primary code of communication that uses vertical eye movements or blinking.

Also known as: Cerebromedullospinal disconnection, Locked In Syndrome, locked-in state

11 clinical trials for this condition and its sub-types, 11 tagged with Locked-in syndrome itself.

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Where it sits in the disease tree

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↑ Nervous system disorder (26588)

Including sub-types (11) Tagged with Locked-in syndrome (11)

Trials to join now! 6 Not yet recruiting 3 Not yet finished but already full! 1 Completed 1

Mind-Reading device may give voice to unconscious patients

Knowledge-focused By invitation only

This study tests a device called mindBEAGLE that reads brain waves to help people with disorders of consciousness answer yes/no questions. Participants wear a cap with sensors, vibrating wristbands, and earphones to learn how to communicate using their thoughts. The goal is to se…

Sponsor: Amy Wagner • Aim: Knowledge-focused

Last updated Jun 27, 2026 13:02 UTC

Locked-in syndrome

Where it sits in the disease tree

Mind-Reading device may give voice to unconscious patients