Localized scleroderma
MONDO:0019562Localized scleroderma is the skin localized form of scleroderma characterized by fibrosis of the skin causing cutaneous plaques or strips.
Also known as: circumscribed scleroderma, localised fibrosing scleroderma, localised scleroderma (disorder) [ambiguous], localized fibrosing scleroderma, localized morphoea, localized scleroderma, localized scleroderma (disorder) [ambiguous], morphea
50 clinical trials for this condition and its sub-types, 14 tagged with Localized scleroderma itself.
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Sub-types of Localized scleroderma
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Linear scleroderma 1 trial
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Lipodermatosclerosis 1 trial
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Cancer drug shows promise for rare skin disease
Disease control CompletedThis study tested whether imatinib, a drug used for certain cancers, can reduce skin hardening in people with severe scleroderma. 28 adults received either imatinib or a placebo for 6 months. The main goal was to see if the drug improved skin thickness and quality of life.
Phase 2 • Sponsor: University Hospital, Bordeaux • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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New device AVELI tackles cellulite and fibrosis in liposuction patients
Symptom relief CompletedThis study tested a device called AVELI to safely reduce cellulite and fibrous tissue in 130 people undergoing body contouring surgery. Researchers measured safety, patient satisfaction, and appearance improvements over 9 months. The goal was to see if adding AVELI to standard li…
Sponsor: Total Definer Research Group • Aim: Symptom relief
Last updated Jun 27, 2026 12:25 UTC
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Could light and simple hand exercises help kids with scleroderma?
Symptom relief CompletedThis study tested whether polarized light therapy combined with hand grip strengthening exercises can help children aged 8 to 11 with localized scleroderma affecting their hands. Twenty-one children took part, doing either resisted hand exercises, light therapy plus exercises, or…
Sponsor: New Ismailia National University • Aim: Symptom relief
Last updated Jun 27, 2026 12:09 UTC
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Scientists probe Immune-Vessel link in rare scleroderma
Knowledge-focused CompletedThis study looked at how blood vessel cells and immune cells talk to each other in people with systemic sclerosis, a rare autoimmune disease that causes skin hardening and organ damage. Researchers collected blood samples and skin biopsies from 350 participants to measure a speci…
Sponsor: University Hospital, Bordeaux • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC