Localized osteosarcoma

This phase II trial tests whether a single infusion of B7-H3 CAR T cells, given after standard chemotherapy, can prevent the return of high-risk osteosarcoma in children. The study will enroll 41 participants who have completed upfront chemotherapy. Researchers will monitor how l…

This study compares two types of surgery to remove lung tumors that have spread from osteosarcoma (a bone cancer). One method uses a single large cut (open surgery), while the other uses several small cuts and a camera (keyhole surgery). The goal is to see which approach helps pa…

This study tests two drugs, atezolizumab and cabozantinib, in 40 adolescents and young adults (ages 12 and up) with osteosarcoma that has come back or spread. Atezolizumab helps the immune system attack cancer cells, while cabozantinib blocks enzymes that help tumors grow. The go…

This study tests a combination of two drugs, apatinib and liposomal irinotecan, in people with advanced osteosarcoma (bone cancer) that has spread or come back after standard treatments. The goal is to find the safest and most effective dose and see if the combo can shrink tumors…

This study tests whether adding four drugs (gefitinib, trametinib, disulfiram, and sunitinib) to standard chemotherapy helps people with osteosarcoma that has spread. About 45 participants with newly diagnosed or advanced disease will be enrolled. Researchers will check if the co…

This phase 2 trial tests whether a year-long maintenance regimen of sirolimus (rapamycin) plus low-dose oral chemotherapy and celecoxib can improve 2-year survival without cancer progression in children with high-risk solid tumors. About 55 children and young adults (ages 1–30) w…

This study tests a special dye called Cytalux that makes cancer cells glow under near-infrared light. Surgeons use it during lung surgery to find and remove hard-to-see tumors in teens (ages 6-17) with bone cancer that has spread to the lungs. The goal is to see if the dye helps …

This study follows 120 patients with localized osteosarcoma (a bone cancer) to collect information on their treatments and outcomes. It does not test a new drug but observes standard care to learn which approaches lead to better survival and fewer side effects. The goal is to imp…

This pilot study looks at 10 people with a new, high-grade bone cancer (osteosarcoma) in an arm or leg. The goal is to see if removing the tumor with surgery before starting chemotherapy leads to better arm or leg function and quality of life. Participants and their surgeons will…