Li-Fraumeni syndrome
MONDO:0018875An autosomal dominant cancer predisposition disorder caused by pathogenic variants in the TP53 gene, characterized by an increased risk of a wide range of cancers, including but not limited to breast cancer, soft tissue sarcomas, osteosarcomas, brain tumors, adrenocortical carcinoma and leukemias.
Also known as: LFS, Li Fraumeni syndrome, Li-Fraumeni familial cancer susceptibility syndrome, Li-Fraumeni syndrome, Li-Fraumeni syndrome caused by mutation in TP53, SBLA syndrome, TP53 Li-Fraumeni syndrome, TP53-related Li-Fraumeni syndrome
47 clinical trials for this condition and its sub-types, 16 tagged with Li-Fraumeni syndrome itself.
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New MRI scans aim to catch cancers before they grow in High-Risk families
Diagnosis By invitation onlyLi-Fraumeni syndrome is a rare genetic condition that greatly increases the risk of developing many types of cancer. This pilot study will test three advanced MRI techniques—whole body STIR MRI, DW-MRI, and PET-MRI—in 30 people with the condition to see how well they can detect v…
Sponsor: The Hospital for Sick Children • Aim: Diagnosis
Last updated Jun 27, 2026 12:24 UTC
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Can Full-Body scans spot cancer early in High-Risk families?
Diagnosis OngoingThis study is testing whether whole body MRI scans can help find cancers early in children and adults with Li-Fraumeni syndrome, a genetic condition that greatly raises cancer risk. About 150 participants will receive annual whole body MRI scans for four years to see if they keep…
Sponsor: Dana-Farber Cancer Institute • Aim: Diagnosis
Last updated Jun 27, 2026 08:08 UTC