Lennox-Gastaut syndrome
MONDO:0016532Lennox-Gastaut syndrome (LGS) belongs to the group of severe childhood epileptic encephalopathies.
Also known as: LGS, encephalopathy of childhood, epileptic encephalopathy Lennox-Gastaut type, macrocephaly and epileptic encephalopathy
40 clinical trials for this condition and its sub-types, 26 tagged with Lennox-Gastaut syndrome itself.
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Sub-types of Lennox-Gastaut syndrome
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Can a new drug curb seizures in children with severe epilepsy?
Disease control CompletedResearchers are testing an experimental drug called TAK-935 in children aged 2 to 17 with Dravet syndrome or Lennox-Gastaut syndrome, two severe forms of epilepsy that often resist treatment. The trial compares TAK-935 added to standard anti-seizure medications against a placebo …
Phase 2 • Sponsor: Takeda • Aim: Disease control
Last updated Sep 16, 2026 00:00 UTC
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New epilepsy drug shows promise in long-term safety trial
Disease control CompletedThis study tested the long-term safety of a drug called LP352 (bexicaserin) in 41 people aged 12 to 65 with severe epilepsy syndromes like Dravet or Lennox-Gastaut. Participants took the drug three times daily for up to 52 weeks. The main goal was to check for side effects, while…
Phase 2 • Sponsor: Longboard Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 08:01 UTC
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New hope for rare seizure patients: Long-Term drug safety confirmed
Disease control CompletedThis study looked at the long-term safety of a drug called fenfluramine (ZX008) for people with rare seizure disorders like Dravet syndrome and Lennox-Gastaut syndrome. A total of 412 participants who had completed earlier studies took the drug and were monitored for side effects…
Phase 3 • Sponsor: Zogenix, Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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Can an experimental drug cut drop seizures in a severe childhood epilepsy?
Symptom relief CompletedResearchers are testing whether soticlestat, an experimental drug, can reduce major drop seizures when added to standard antiseizure therapy in children, teenagers, and adults with Lennox-Gastaut syndrome. About 270 participants will take either soticlestat or a placebo for 16 we…
Phase 3 • Sponsor: Takeda • Aim: Symptom relief
Last updated Sep 12, 2026 00:00 UTC
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How many people live with rare epilepsies in spain? a nationwide count aims to find out
Knowledge-focused CompletedThis study looks at medical records from public hospitals in Spain to count how many children, teenagers, and adults have Dravet syndrome or Lennox-Gastaut syndrome, and how many new cases are diagnosed each year. It is an observational study, meaning no treatment or intervention…
Sponsor: Takeda • Aim: Knowledge-focused
Last updated Aug 20, 2026 00:00 UTC