Lafora disease

MONDO:0009697

Lafora disease (LD) is a rare, inherited, severe, progressive myoclonic epilepsy characterized by myoclonus and/or generalized seizures, visual hallucinations (partial occipital seizures), and progressive neurological decline.

Also known as: EPM2, Lafora disease, PME type 2, epilepsy, progressive myoclonic 2A (Lafora), epilepsy, progressive myoclonic 2B (Lafora), myoclonic epilepsy of Lafora, progressive myoclonic epilepsy type 2, progressive myoclonus epilepsy type 2

21 clinical trials for this condition and its sub-types, 1 tagged with Lafora disease itself.

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Where it sits in the disease tree

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Part of

↑ Movement disorder (805) ↑ Disorder of glycogen metabolism (69) ↑ Progressive myoclonus epilepsy (12)

Sub-types of Lafora disease

Myoclonic epilepsy of Lafora 1 0 trials
Myoclonic epilepsy of Lafora 2 0 trials

Including sub-types (21) Tagged with Lafora disease (1)

Trials to join now! 1

New hope for rare epilepsy: drug ION283 enters human trials

Disease control Recruiting now

This study tests a new drug called ION283 in 10 people aged 10 to 18 with Lafora disease, a rare and severe form of epilepsy. The drug is given via a spinal injection to see if it is safe and can help control seizures and other symptoms. All participants will receive the same dos…

Phase 1/2 • Sponsor: Berge Minassian • Aim: Disease control

Last updated Jun 27, 2026 08:05 UTC

Lafora disease

Where it sits in the disease tree

New hope for rare epilepsy: drug ION283 enters human trials