Iridocorneal endothelial syndrome

MONDO:0018988

Iridocorneal endothelial (ICE) syndrome describes a group of progressive corneal proliferative endotheliopathies comprised of Chandler syndrome, Cogan-Reese syndrome and essential iris atrophy, affecting mainly young adult females and characterized by iris holes and atrophy, papillary distortion, anterior synechiae, corneal edema and often with secondary glaucoma and corneal decompensation as complications

Also known as: ICE syndrome

3 clinical trials for this condition and its sub-types, 1 tagged with Iridocorneal endothelial syndrome itself.

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Where it sits in the disease tree

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Sub-types of Iridocorneal endothelial syndrome

Including sub-types (3) Tagged with Iridocorneal endothelial syndrome (1)

Not yet finished but already full! 1

Eye transplant showdown: which surgery saves sight best?

Disease control Ongoing

This study compares two types of corneal transplant surgery (UT-DSAEK and DMEK) in 160 people with Fuchs dystrophy, a condition that clouds the cornea. It also tests whether a drug called rho-kinase inhibitor can reduce loss of important eye cells after surgery. The goal is to fi…

Phase 3 • Sponsor: Stanford University • Aim: Disease control

Last updated Aug 19, 2026 00:00 UTC

Iridocorneal endothelial syndrome

Where it sits in the disease tree

Eye transplant showdown: which surgery saves sight best?