Hypoplastic left heart syndrome
MONDO:0004933Hypoplastic left heart syndrome (HLHS) refers to the abnormal development of the left-sided cardiac structures, resulting in obstruction to blood flow from the left ventricular outflow tract. In addition, the syndrome includes underdevelopment of the left ventricle, aorta, and aortic arch, as well as mitral atresia or stenosis.
Also known as: HLHS
85 clinical trials for this condition and its sub-types, 10 tagged with Hypoplastic left heart syndrome itself.
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Sub-types of Hypoplastic left heart syndrome
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Hypoplastic left heart syndrome 1 0 trials
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Hypoplastic left heart syndrome 2 0 trials
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Could a child's own stem cells strengthen a weak heart after surgery?
Disease control Recruiting nowThis study tests whether injecting a child's own heart stem cells (JRM-001) after reconstructive surgery can improve heart function in children with single ventricle heart defects. About 40 children scheduled for Glenn or Fontan surgery will receive either the stem cells or a pla…
Phase 3 • Sponsor: Metcela Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
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Moms' stress in pregnancy linked to baby brain outcomes in heart defect study
Knowledge-focused Recruiting nowThis study looks at 174 mothers whose babies were diagnosed with serious heart defects before birth. Researchers will track the mothers' mental health from the third trimester until the baby is one year old, and then test the babies' brain development. The goal is to understand i…
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France • Aim: Knowledge-focused
Last updated Aug 01, 2026 00:00 UTC
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Heart disease patients join forces to shape future research
Knowledge-focused Recruiting nowThis study creates a registry for 500 people with congenital heart disease (CHD) and their caregivers. Participants share their medical history to help researchers understand the disease better and design future clinical trials. Unlike a typical registry, members will actively gu…
Sponsor: HeartWorks, Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC