Hypopituitarism
MONDO:0005152A condition of diminution or cessation of secretion of one or more hormones from the anterior pituitary gland. This may result from surgical or radiation ablation, non-secretory pituitary neoplasms, metastatic tumors, infarction, pituitary apoplexy, infiltrative or granulomatous processes, and other conditions.
Also known as: pituitary insufficiency
47 clinical trials for this condition and its sub-types, 5 tagged with Hypopituitarism itself.
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Sub-types of Hypopituitarism
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Combined pituitary hormone deficiencies, genetic form 1 trial · 42 incl. sub-types
9 sub-types
- Isolated congenital growth hormone deficiency 38 trials Sub-types →
- Panhypopituitarism 2 trials Sub-types →
- Congenital isolated adrenocorticotropic hormone deficiency 1 trial
- Pituitary hormone deficiency, combined, 1 1 trial
- Septooptic dysplasia 1 trial Sub-types →
- Non-acquired combined pituitary hormone deficiency with spine abnormalities 0 trials
- Pituitary hormone deficiency, combined or isolated, 8 0 trials
- Pituitary hormone deficiency, combined, 6 0 trials
- Short stature-pituitary and cerebellar defects-small sella turcica syndrome 0 trials
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Acquired pituitary hormone deficiency 0 trials · 1 incl. sub-types
4 sub-types
- Pituitary apoplexy 1 trial
- Iatrogenic or traumatic pituitary deficiency 0 trials
- Late-onset isolated ACTH deficiency 0 trials
- Primary hypophysitis 0 trials Sub-types →
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Kaplowitz-Bodurtha syndrome 0 trials
Most studied deeper sub-types
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Hormone pill could unlock diagnosis of rare oxytocin deficiency in teens
Diagnosis Recruiting nowThis early-phase trial is testing whether a single dose of a hormone pill can help diagnose oxytocin deficiency in young people with hypopituitarism. Researchers will give the pill to 20 participants and measure oxytocin-related substances in blood and saliva. The goal is to deve…
Early phase 1 • Sponsor: Massachusetts General Hospital • Aim: Diagnosis
Last updated Aug 23, 2026 00:00 UTC
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Could a nasal spray ease anxiety in a rare hormone disorder?
Symptom relief Recruiting nowThis pilot study is testing whether an oxytocin nasal spray can help with anxiety, depression, and social functioning in adults with arginine-vasopressin deficiency, a rare hormone disorder. In the first part, 30 participants will receive single doses of oxytocin or placebo and c…
Phase 1 • Sponsor: Elizabeth Austen Lawson • Aim: Symptom relief
Last updated Jul 25, 2026 00:00 UTC
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Can treating a hidden hormone problem after brain injury restore quality of life?
Knowledge-focused Recruiting nowThis study looks at adults who had a traumatic brain injury at least a year ago. Researchers want to see whether those with growth hormone deficiency have worse quality of life, fatigue, mood, and sleep than those without it. Participants complete questionnaires and a test for gr…
Sponsor: University of Calgary • Aim: Knowledge-focused
Last updated Sep 02, 2026 00:00 UTC
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Brain injury linked to poor sleep: new study seeks answers
Knowledge-focused Recruiting nowThis study looks at why people with damage to the hypothalamus or pituitary gland often have sleep problems. Researchers will compare 60 patients to healthy volunteers using sleep tests, hormone measurements, and brain scans. The goal is to find better ways to prevent and treat t…
Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC