Hypogonadism

This study tests whether kisspeptin, a natural hormone, can stimulate reproductive hormones and egg release in 36 men and women with idiopathic hypogonadotropic hypogonadism (IHH). Participants receive kisspeptin injections every 1-4 hours for two weeks. Researchers monitor hormo…

This study tests whether kisspeptin, a natural hormone, can trigger the release of other reproductive hormones and help women with hypothalamic amenorrhea (missing periods) release eggs. Twenty women will receive daily injections of kisspeptin for two weeks, with frequent blood t…

This phase 3 trial is testing XYOSTED, a testosterone injection, in 100 adolescent males who lack or have low testosterone due to hypogonadism. The study lasts 52 weeks, with a 24-month safety follow-up, and aims to see if the treatment can safely induce or continue puberty. Part…

This trial tests whether altering sex hormone levels can make muscles, tendons, and bones more resilient to the physical and mental stress of military-style training. Healthy adults aged 18-40 will undergo a 4-week training program, with some receiving goserelin to suppress hormo…

This study tests whether giving testosterone to men with chronic back pain who take opioids can improve their pain, sexual function, fatigue, and quality of life. The men have low testosterone caused by opioids. Half will get testosterone injections and half a placebo. The trial …

This study tests whether a testosterone drug (Depo-Testosterone) can reduce fatigue and improve sexual function, mood, and body composition in young men (ages 18-54) who have survived cancer and now have low testosterone. Participants must be in remission for at least one year an…

This study tests whether giving testosterone injections every 15 days can improve quality of life for men with low testosterone who are receiving best supportive care and have no further treatment options. Researchers will track symptoms like pain, fatigue, and daily living activ…

This study tests small hormone implants placed under the skin to relieve menopause symptoms like hot flashes, low mood, and sexual problems. It includes 140 women with natural menopause, early ovarian failure, or menopause from cervical cancer treatment. Researchers will check ho…

This study looks at how things in your environment—like pollution, chemicals, diet, and sleep—might affect your hormones and reproductive health. Researchers will follow 300 people aged 8 and older who have conditions like low or high hormone levels, early or late puberty, or inf…

This study will examine 600 men aged 35-59 in Uzbekistan to find out which physical, lifestyle, and emotional factors are linked to low testosterone. Participants will have blood tests, physical measurements, and complete questionnaires. The goal is to create a model that helps d…

This study aims to understand how reproductive disorders, such as delayed or early puberty, are inherited. Researchers will collect blood samples and medical histories from 850 people with these conditions and their family members. No treatment is provided; the goal is to identif…

This observational study follows 150 people with MEHMO syndrome or related conditions to better understand how the disease progresses. Researchers will collect medical history, imaging, and lab samples to find biological markers that could help monitor the disease. No treatment i…

This study surveys 400 men undergoing ICSI due to low sperm quality. Researchers want to understand their emotional experiences, social burden, and testosterone levels, and compare results to a similar study from 2008. The goal is to see if men's needs in fertility care have chan…

This study tests a new, radiation-free ultrasound technology called REMS to measure bone density in children aged 5 to 18 who have conditions that weaken bones, such as brittle bone disease or osteoporosis. The goal is to see if REMS can work as well as the standard X-ray method …

This study is testing whether a simple finger device called EndoPAT can measure blood vessel function in men aged 30–50 with erectile dysfunction or low testosterone. About 120 men will use the device before and after taking daily low-dose ED medication or testosterone therapy. T…

This study at Strasbourg University Hospital surveys 20 teenage girls (ages 11-18) with female hypogonadism and their parents to assess their knowledge of hormone replacement therapy. The goal is to identify gaps in understanding so that better educational workshops can be design…

This study looks at why men with spinal cord injury often have low testosterone and how that might damage blood vessels, raising the risk of heart attacks and strokes. Researchers will test blood vessel function in 48 men with recent spinal cord injury and low testosterone. They …