Hyperplastic polyposis syndrome

MONDO:0015524

Hyperplastic polyposis syndrome is a rare, genetic intestinal disease characterized by the presence of multiple (usually large) hyperplastic/serrated colorectal polyps, usually with a pancolonic distribution. Histology reveals hyperplastic polyps, sessile serrated adenomas (most common), traditional serrated adenomas or mixed polyps. It is associated with an increased personal and familial (first-degree relatives) risk of colorectal cancer.

Also known as: serrated polyposis

35 clinical trials for this condition and its sub-types, 1 tagged with Hyperplastic polyposis syndrome itself.

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Where it sits in the disease tree

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Part of

↑ Digestive system disorder (16339) ↑ Intestinal polyposis syndrome (53)

Sub-types of Hyperplastic polyposis syndrome

Colon serrated polyposis 1 trial
Sessile serrated polyposis cancer syndrome 0 trials

Including sub-types (35) Tagged with Hyperplastic polyposis syndrome (1)

Completed 1

Bacteria in mouth and gut may hold clues to colon polyp risk

Knowledge-focused Completed

This study looked at the bacteria in the mouth and gut of 126 people with and without serrated polyposis syndrome, a condition that raises the risk of colorectal cancer. Researchers compared the bacteria in people with the syndrome to those with other types of polyps or no polyps…

Sponsor: Hospital Universitari Vall d'Hebron Research Institute • Aim: Knowledge-focused

Last updated Jun 27, 2026 08:04 UTC

Hyperplastic polyposis syndrome

Where it sits in the disease tree

Bacteria in mouth and gut may hold clues to colon polyp risk