Hyperphosphatemia

This study follows adults with chronic kidney disease who are on dialysis and starting the phosphate binder Nephoxil for high blood phosphorus. Researchers track patients for 48 weeks to see how many reach a target phosphorus level of 3.5 to 5.5 mg/dL, using either a low or stand…

This study investigates whether giving phosphate through an IV can reduce the severity of acute pancreatitis in adults. Researchers want to know if low phosphate levels make the disease worse and if replenishing it helps. Participants receive either standard care or IV phosphate …

This trial asks whether aggressively lowering blood phosphate levels in people with end-stage kidney disease on dialysis can reduce heart attacks, strokes, and death. Participants are randomly assigned to either a liberal phosphate target or an intensive target aimed at normal le…

This study tests a new drug called AP306 in 168 adults on maintenance hemodialysis who have high phosphate levels (hyperphosphatemia). Participants take one of several fixed doses of AP306 or a placebo daily for 8 weeks. The main goal is to see if AP306 safely lowers blood phosph…

This study tests a new drug called TS-172 in 30 adults on peritoneal dialysis who have high phosphorus levels. Participants take the drug daily for several weeks to see if it can safely bring their phosphorus down to a target range. The goal is to find a better way to manage this…

This study tests a new drug called TS-172 in 30 adults on hemodialysis who have high phosphate levels. Participants take the drug daily for a period, and researchers check if their phosphate levels drop to a target range. The goal is to see if TS-172 can help control phosphate, a…

This study tests an experimental drug called TS-172 in 100 adults on hemodialysis who have high phosphorus levels. Participants will take TS-172 or a placebo alongside their usual phosphate binders. The goal is to see if TS-172 helps more patients reach safe phosphorus levels, wh…

This phase 3 trial tests whether AP301, a drug taken with meals, can safely lower high blood phosphate in people on kidney dialysis. About 264 participants will receive either AP301 or a low-dose version for 8 weeks, then all get AP301 for 24 weeks. The goal is to see if AP301 he…

This phase 3 study tests a new drug called TS-172 in 300 adults on hemodialysis who have high phosphate levels. Participants take the pill daily for up to a year to see if it safely and effectively controls phosphate. The goal is to offer a better treatment option for a common co…

This study aims to collect information and bone samples from up to 1,000 people with bone or mineral disorders, such as tumor-induced osteomalacia or familial tumoral calcinosis. Participants receive standard medical evaluations and may provide bone tissue from surgery or a biops…

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This study looks at whether eating too much phosphate—common in many US diets—can reduce your ability to exercise and increase belly fat. Researchers will measure oxygen use during cycling and energy production in muscles. About 124 healthy adults will take part to see if finding…