Hyper-IgM syndrome

MONDO:0003947

A primary immune deficiency disorder characterized by defective CD40 signaling; via B cells affecting class switch recombination (CSR) and somatic hypermutation.

Also known as: immunodeficiency with hyper-IgM, hyperimmunoglobulin M syndrome

50 clinical trials for this condition and its sub-types, 8 tagged with Hyper-IgM syndrome itself.

Follow this condition to get notified about new trials

Where it sits in the disease tree

Browse by category →

Part of

↑ Hyperimmunoglobulin syndrome (33)

Sub-types of Hyper-IgM syndrome

Including sub-types (50) Tagged with Hyper-IgM syndrome (8)

Trials to join now! 3 Not yet finished but already full! 4 Completed 1

Lupus clue: can a heart drug reveal hidden disease markers?

Knowledge-focused Completed

This small pilot study looked at whether clopidogrel, a drug that stops blood clots, could lower a substance called sCD40L in people with lupus. Lupus is an autoimmune disease where the body attacks itself. The study involved 18 adults with lupus and measured sCD40L levels in the…

Phase 1/2 • Sponsor: University Hospital, Bordeaux • Aim: Knowledge-focused

Last updated Jun 27, 2026 12:33 UTC

Hyper-IgM syndrome

Where it sits in the disease tree

Lupus clue: can a heart drug reveal hidden disease markers?