Hepatosplenic T-cell lymphoma
MONDO:0019474An extranodal, mature T-cell non-Hodgkin lymphoma that originates from cytotoxic T-cells, usually of gamma/delta T-cell type. It is characterized by the presence of medium-size neoplastic lymphocytes infiltrating the hepatic sinusoids. A similar infiltrating pattern is also present in the spleen and bone marrow that are usually involved at the time of the diagnosis.
Also known as: Hepatosplenic gamma/Delta T-cell lymphoma, HSTCL
1943 clinical trials for this condition and its sub-types, 16 tagged with Hepatosplenic T-cell lymphoma itself.
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Can adding linperlisib to standard chemotherapy improve outcomes in rare T-Cell lymphoma?
Disease control OngoingResearchers are testing whether adding the experimental drug linperlisib to standard CHOP chemotherapy helps people with newly diagnosed peripheral T-cell lymphoma. The trial enrolls about 44 participants who have not received prior treatment. Everyone receives six cycles of the …
Phase 1/2 • Sponsor: Sun Yat-sen University • Aim: Disease control
Last updated Sep 18, 2026 00:00 UTC
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New combo shows promise against tough lymphoma
Disease control OngoingThis phase 2 trial tests a new combination treatment for a rare type of lymphoma (CD30-positive peripheral T-cell lymphoma). It combines a targeted drug (brentuximab vedotin) with standard chemotherapy. The goal is to see if this approach improves the number of patients who achie…
Phase 2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Aug 23, 2026 00:00 UTC
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Engineered donor cells take aim at tough blood cancers in early trial
Disease control PausedThis early-phase trial tests a new type of immune cell therapy called WU-CART-007 for people with certain blood cancers, including acute myeloid leukemia and T-cell lymphoma, that have come back or not responded to treatment. The therapy uses donor cells that are genetically modi…
Phase 1 • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Jul 23, 2026 00:00 UTC
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Vitamin d boost may extend life in lymphoma patients, trial hopes
Disease control OngoingThis study looks at whether giving vitamin D supplements to people with newly diagnosed lymphoma or chronic lymphocytic leukemia who have low vitamin D levels can improve their survival and delay the need for treatment. About 565 participants are being given vitamin D3 or a place…
Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Promising combo tackles rare blood cancer in chinese patients
Disease control OngoingThis study tests a combination of brentuximab vedotin plus standard chemotherapy (CHP) in 52 Chinese adults with a rare type of lymphoma called CD30+ peripheral T-cell lymphoma. The goal is to see how well the treatment shrinks tumors and to monitor side effects. Participants rec…
Phase 2 • Sponsor: Takeda • Aim: Disease control
Last updated Jun 27, 2026 13:05 UTC