Hemoglobinopathy
MONDO:0044348Also known as: hemoglobinopathy, globin abnormality, haemoglobin disease, haemoglobin disorder, hemoglobin disease, hemoglobin disorder
445 clinical trials for this condition and its sub-types, 34 tagged with Hemoglobinopathy itself.
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Sub-types of Hemoglobinopathy
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Inherited hemoglobinopathy 38 trials · 439 incl. sub-types
17 sub-types
- Sickle cell disease 342 trials Sub-types →
- Thalassemia 49 trials · 129 incl. sub-types Sub-types →
- Beta-thalassemia and related diseases 0 trials · 99 incl. sub-types Sub-types →
- Congenital nonspherocytic hemolytic anemia 1 trial · 12 incl. sub-types Sub-types →
- Sickle cell-beta-thalassemia disease syndrome 5 trials · 9 incl. sub-types Sub-types →
- Hemoglobin C disease 2 trials
- Hereditary methemoglobinemia 0 trials · 1 incl. sub-types Sub-types →
- Unstable hemoglobin disease 1 trial
- Hemoglobin D disease 0 trials
- Hemoglobin E disease 0 trials
- Hemoglobinopathy Toms River 0 trials
- Hereditary persistence of fetal hemoglobin 0 trials
- Hereditary persistence of fetal hemoglobin-sickle cell disease syndrome 0 trials
- Homozygous hemoglobin O Arab disease 0 trials
- Sickle cell-hemoglobin E disease syndrome 0 trials
- Sickle cell-hemoglobin d disease syndrome 0 trials
- Sulfhemoglobinemia, congenital 0 trials
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Methemoglobinemia 2 trials · 3 incl. sub-types
2 sub-types
- Hereditary methemoglobinemia 0 trials · 1 incl. sub-types Sub-types →
- Drug-induced methemoglobinemia 0 trials
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Acquired hemoglobinopathy 0 trials
1 sub-type
- Drug-induced methemoglobinemia 0 trials
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Sulfhemoglobinemia 0 trials
1 sub-type
- Sulfhemoglobinemia, congenital 0 trials
Most studied deeper sub-types
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Gene editing offers hope for a One-Time sickle cell cure
Cure CompletedResearchers are testing a one-time gene therapy called exa-cel for people with severe sickle cell disease. The treatment uses CRISPR-Cas9 to edit a patient's own blood stem cells, which are then infused back after chemotherapy. The trial measures whether participants remain free …
Phase 2/3 • Sponsor: Vertex Pharmaceuticals Incorporated • Aim: Cure
Last updated Sep 18, 2026 00:00 UTC
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New cord blood matching method could expand transplant access for blood cancer patients
Disease control CompletedThis study tests a new approach to stem cell transplants for people with blood cancers like leukemia and lymphoma. Patients receive a combination of umbilical cord blood and stem cells from a family member, with the cord blood chosen based on specific genetic markers rather than …
Phase 2 • Sponsor: Weill Medical College of Cornell University • Aim: Disease control
Last updated Aug 21, 2026 00:00 UTC
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Gentler transplant shows promise for kids with blood diseases
Disease control CompletedThis study tests a milder chemotherapy and immune-suppressing regimen before a stem cell transplant for children and young adults with non-malignant blood disorders like sickle cell disease or immune deficiencies. The goal is to safely achieve donor cell engraftment with fewer si…
Phase 2 • Sponsor: Children's Hospital of Philadelphia • Aim: Disease control
Last updated Jul 23, 2026 00:00 UTC
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CRISPR gene editing offers hope for thalassemia patients to ditch transfusions
Disease control CompletedThis study tested a single treatment using CRISPR gene editing to modify a person's own blood stem cells, aiming to help people with severe beta-thalassemia stop needing regular blood transfusions. 59 participants received the therapy and were monitored for safety and how long th…
Phase 2/3 • Sponsor: Vertex Pharmaceuticals Incorporated • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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New chemo combo may lower death risk in child stem cell transplants
Disease control CompletedThis study tested two different chemotherapy drugs (Treosulfan and Busulfan) given before a stem cell transplant in 106 children with serious non-cancer diseases like immune disorders, metabolic diseases, blood disorders, and bone marrow failure. The goal was to see which drug le…
Phase 2 • Sponsor: medac GmbH • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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8,400 screened in bangladesh to uncover hidden blood disorders
Knowledge-focused CompletedThis study screened 8,400 people living in Chattogram, Bangladesh to find out how common abnormal hemoglobin types are. Researchers used a blood test called HbA1c capillary electrophoresis to detect conditions like HbE trait. The goal was to understand the prevalence of these inh…
Sponsor: Bangladesh Bioscience Research Group • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC
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Blood disorder survey in bangladesh reveals hidden genetic burden
Knowledge-focused CompletedThis completed study looked at how often hemoglobin disorders (like thalassemia and sickle cell disease) occur in people visiting a hospital in Chattogram, Bangladesh. Researchers tested blood samples from 760 volunteers using advanced methods to find different hemoglobin types. …
Sponsor: Bangladesh Bioscience Research Group • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC
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Blood disorder survey reveals regional patterns in pakistan
Knowledge-focused CompletedThis completed study checked how often inherited blood disorders (hemoglobinopathies) occur in people from Mardan, Pakistan, and nearby areas. Researchers analyzed blood samples from 839 people using special lab tests. The goal was to gather local data to help improve public heal…
Sponsor: Bacha Khan Medical College • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:45 UTC