Hemoglobin H disease
MONDO:0013512Alpha thalassemia caused by variation in three of the four copies of the alpha hemoglobin genes (e.g., large deletion in HBA1 and HBA2 genes in trans with a variant in either HBA1 or HBA2).
Also known as: Alpha-thalassemia intermedia, HBA1;HBA2 digenic triallelic hemoglobin H disease, HBH, HbH, HbH disease, alpha-thalassemia intermedia, haemoglobin H disease, deletional and nondeletional, hemoglobin H disease
21 clinical trials for this condition and its sub-types, 5 tagged with Hemoglobin H disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →-
New drug could cut transfusions for rare blood disorder
Disease control OngoingThis phase 2 trial tests luspatercept (Reblozyl) in adults and adolescents with alpha-thalassemia, a genetic blood disorder that causes anemia. The goal is to see if the drug can reduce the need for blood transfusions and raise hemoglobin levels. About 189 participants will recei…
Phase 2 • Sponsor: Bristol-Myers Squibb • Aim: Disease control
Last updated Sep 12, 2026 00:00 UTC
-
New pill could boost red blood cells in thalassemia patients
Disease control OngoingThis phase 3 trial tests whether the drug mitapivat can improve anemia and reduce fatigue in people with alpha- or beta-thalassemia who do not need regular blood transfusions. About 194 participants received either mitapivat or a placebo daily for 24 weeks. The main goal is to se…
Phase 3 • Sponsor: Agios Pharmaceuticals, Inc. • Aim: Disease control
Last updated Aug 29, 2026 00:00 UTC
-
Tiny study probes Mitapivat's inner workings in sickle cell
Knowledge-focused OngoingThis observational study will examine how the drug mitapivat changes red blood cells in 6 people with sickle cell disease. Researchers will measure oxygen binding and cell survival markers from blood samples and muscle oxygen tests. The goal is to understand the drug's effects, n…
Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC