Head injury

This trial tests a new approach to face transplantation that aims to reduce the need for lifelong, high-dose immunosuppressive drugs. The method combines a bone marrow cell infusion with a single low-dose immunosuppressant, potentially lowering the risk of infection, cancer, and …

This study tests whether transplanting a face and hands together can help people with severe injuries that standard surgery and prosthetics cannot fix. Ten adults aged 18-64 will receive the transplant and be monitored for changes in function and appearance using tests like EMG, …

This study is testing whether a special ultrasound of the brain's blood vessels can accurately diagnose brain injuries in newborns. Researchers will use transcranial Doppler ultrasound on 60 high-risk babies to see how well it detects problems. If it works, it could offer a safer…

This study is testing whether a blood test for a protein called S100B can help doctors quickly rule out brain injury in people who come to the emergency room with a head injury. The test is already known to be very accurate at predicting when no brain injury is present. If it wor…

This trial explores whether combining cognitive training with a gentle electrical brain stimulation technique, called tDCS, can help improve working memory in people who have had a moderate to severe head injury. Participants will go through a 5-month program that includes memory…

This study tests two behavioral treatments—cognitive behavioral therapy (CBT) and mindfulness—to help people with traumatic brain injury (TBI) sleep better and feel less stressed. 360 veterans and service members with mild to moderate TBI, insomnia, and PTSD symptoms will receive…

This study tests whether using RECELL® — a device that creates a spray from a patient's own skin cells — can improve skin color matching after head and neck reconstructive surgery. Twenty adults who need this surgery will receive the treatment, and their color match, healing, and…

This study tests a personalized, noninvasive brain stimulation technique called TMS for people aged 18–65 with chronic symptoms after a mild concussion or traumatic brain injury. Symptoms like headache, dizziness, brain fog, and anxiety can last for months. Participants will rece…

This study follows over 2,500 teens aged 11 to 17 who come to the emergency room with a mild traumatic brain injury (mTBI). Researchers want to see if they develop new or worsening depression or anxiety in the months after injury. Teens and their parents fill out questionnaires a…

This study looks at 200 children with minor head trauma to see if family education, income, and health literacy influence parents asking for a CT scan. Doctors already have a rule (PECARN) to decide when a CT is needed, but parents sometimes request one anyway. The goal is to und…

This study is developing a checklist to help doctors decide when it's safe to skip a CT scan for head injuries in patients taking blood thinners. Researchers will study 4,000 emergency department patients to find out which symptoms or signs reliably rule out serious brain bleedin…

This study looks back at the records of 4,500 adults with mild head injuries treated in emergency rooms in the Emilia-Romagna region of Italy. Researchers want to see how often serious complications like brain bleeding occur and compare two common rules doctors use to decide if a…

This study looks at whether patients who take antiplatelet drugs (blood thinners) and have a minor head injury, but no other signs of brain bleeding, still need a CT scan. Current guidelines recommend a scan for these patients, but the evidence is weak. The study will follow 3,20…