GRN-related frontotemporal lobar degeneration with Tdp43 inclusions
MONDO:0011842A frontotemporal dementia characterized by variable phenotypic expression typically including social, behavioral, or language deterioration, rather than memory or motor deficits and the presence of TARDBP-positive inclusions that has material basis in mutation in the GRN gene on chromosome 17q21.31.
Also known as: FTLD-TDP, GRN-related, aphasia, primary progressive, dementia, hereditary dysphasic disinhibition, frontotemporal dementia with TDP43 inclusions, GRN-related, frontotemporal dementia, ubiquitin-positive, frontotemporal lobar degeneration with TDP43 inclusions, GRN-related, frontotemporal lobar degeneration with ubiquitin-positive inclusions
51 clinical trials for this condition and its sub-types, 6 tagged with GRN-related frontotemporal lobar degeneration with Tdp43 inclusions itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of GRN-related frontotemporal lobar degeneration with Tdp43 inclusions
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Progressive non-fluent aphasia 24 trials · 44 incl. sub-types
1 sub-type
- Semantic dementia 32 trials Sub-types →
Most studied deeper sub-types
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Gene therapy infused directly into brain aims to halt rare dementia
Disease control Recruiting nowThis early-phase trial tests a gene therapy called AVB-101 for people with frontotemporal dementia caused by GRN gene mutations. The therapy delivers a working copy of the GRN gene directly into the brain during a one-time procedure. The study will enroll 18 adults aged 30-75 to …
Phase 1/2 • Sponsor: AviadoBio Ltd • Aim: Disease control
Last updated Aug 15, 2026 00:00 UTC
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Could a common heart drug help slow language loss in dementia?
Symptom relief Recruiting nowThis early-phase trial tests whether propranolol, a drug typically used for high blood pressure, can improve language abilities and reduce anxiety in older adults with primary progressive aphasia (PPA). PPA is a type of dementia that gradually impairs speech and language, and the…
Early phase 1 • Sponsor: University of Missouri-Columbia • Aim: Symptom relief
Last updated Jul 19, 2026 00:00 UTC
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Can tracking brain changes over time unlock the secrets of frontotemporal dementia?
Knowledge-focused Recruiting nowThis long-term study follows people with or at genetic risk for frontotemporal lobar degeneration (FTLD), a group of brain disorders that cause changes in behavior, language, and movement. Researchers will use brain scans, memory tests, and blood samples to measure how the diseas…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Aug 01, 2026 00:00 UTC