Granulomatous disease, chronic, X-linked
MONDO:0010600Also known as: CGD, chronic granulomatous disease, X-linked, chronic granulomatous disease, X-linked, X-linked recessive, chronic granulomatous disease, atypical, cytochrome B-negative granulomatous disease, chronic, X-linked, cytochrome B-positive granulomatous disease, chronic, X-linked, granulomatous disease, chronic, X-linked, granulomatous disease, chronic, X-linked, variant
52 clinical trials for this condition and its sub-types, 10 tagged with Granulomatous disease, chronic, X-linked itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →-
Can a new antibody make stem cell transplants safer for CGD patients?
Cure OngoingChronic granulomatous disease (CGD) is a rare immune disorder that causes severe infections, and the only cure is a stem cell transplant. Transplants from unrelated donors can be risky, so researchers are testing whether adding the drug JSP191 before the transplant helps the dono…
Early phase 1 • Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Cure
Last updated Aug 29, 2026 00:00 UTC
-
Gene fix trial aims to tame rare immune disease
Disease control By invitation onlyThis study tests a gene therapy for people with X-linked chronic granulomatous disease (X-CGD), a genetic condition that weakens the immune system and leads to severe infections. Researchers take the patient's own stem cells, add a working copy of the faulty gene, and return the …
Phase 1/2 • Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Disease control
Last updated Sep 10, 2026 00:00 UTC
-
Gene therapy aims to fix immune system in rare disease
Disease control OngoingThis study tests a one-time gene therapy called EN-374 for people with X-linked chronic granulomatous disease (X-CGD), a rare immune disorder that causes severe infections. The treatment uses a modified virus to deliver a working gene to blood stem cells, aiming to restore the ab…
Phase 1/2 • Sponsor: Ensoma • Aim: Disease control
Last updated Aug 23, 2026 00:00 UTC
-
Gene therapy hope for rare immune disease fails to launch
Disease control CancelledThis trial aimed to test a gene therapy for X-linked chronic granulomatous disease, a condition where the immune system cannot fight certain infections. The treatment involved taking the patient's own stem cells, adding a working copy of the defective gene, and returning them to …
Phase 1/2 • Sponsor: Helixmith Co., Ltd. • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC