Granulomatous disease, chronic, X-linked
MONDO:0010600Also known as: CGD, chronic granulomatous disease, X-linked, chronic granulomatous disease, X-linked, X-linked recessive, chronic granulomatous disease, atypical, cytochrome B-negative granulomatous disease, chronic, X-linked, cytochrome B-positive granulomatous disease, chronic, X-linked, granulomatous disease, chronic, X-linked, granulomatous disease, chronic, X-linked, variant
52 clinical trials for this condition and its sub-types, 10 tagged with Granulomatous disease, chronic, X-linked itself.
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MRNA therapy gives immune cells a temporary boost against rare infection disease
Disease control Recruiting nowThis early-stage trial tests a new approach for chronic granulomatous disease (CGD), a genetic condition that leaves people vulnerable to severe infections. Researchers take a participant's own white blood cells, use mRNA to correct the genetic defect, and infuse the cells back. …
Phase 1 • Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Disease control
Last updated Sep 06, 2026 00:00 UTC
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Gene-Editing breakthrough aims to fix immune cells in rare disease
Disease control Recruiting nowThis early-stage trial tests a new gene-editing approach for X-linked chronic granulomatous disease (X-CGD), a rare immune disorder. Researchers will collect stem cells from 10 adult male participants, use base editing to correct the genetic mutation, and return the cells after m…
Phase 1/2 • Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Disease control
Last updated Aug 15, 2026 00:00 UTC
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New drug cocktail aims to boost stem cell harvest for rare immune disease
Disease control Recruiting nowThis phase II trial tests whether a combination of ibuprofen, G-CSF, and plerixafor can safely and effectively mobilize stem cells from the bone marrow into the blood in people with X-linked chronic granulomatous disease (X-CGD). Only 3 adults aged 18-45 are being enrolled. The g…
Phase 2 • Sponsor: IRCCS San Raffaele • Aim: Disease control
Last updated Jun 26, 2026 18:36 UTC