Grade II meningioma

This phase III trial compares radiation therapy to simple observation in patients who have had a grade II meningioma completely removed by surgery. The goal is to see if radiation helps keep the tumor from coming back. About 163 participants will be randomly assigned to either re…

This pilot trial is testing a type of radiation called hypofractionated stereotactic radiosurgery for people who have had surgery for a grade II or recurrent grade I meningioma. The treatment delivers higher doses of radiation in fewer sessions, which may kill leftover tumor cell…

This study tests an oral drug called JZP3507 (ONC206) in 30 adults with recurrent grade 2 or 3 meningioma, a type of brain tumor. Participants take the drug three days a week in 28-day cycles. The main goal is to see if the drug can shrink tumors, with safety and response duratio…

This phase IIb trial tests whether combining the drug everolimus with a targeted radiation therapy (177Lu-DOTATATE) can slow tumor growth in people with grades 2 and 3 meningioma that no longer responds to surgery or radiation. About 28 adults will receive the combination for 7 m…

This study tests a radioactive drug called Lutathera for people with a type of brain tumor (meningioma) that cannot be removed by surgery and has continued to grow after radiation therapy. The drug is given through a vein and targets tumor cells to stop them from growing. The tri…

This study tests a shorter course of high-dose proton radiation for people with non-cancerous brain tumors like meningiomas and schwannomas. The goal is to see if fewer treatments can still control tumor growth while reducing side effects and being more convenient. About 70 adult…

This study is looking for 500 people with certain cancers (like eye or skin melanoma, kidney cancer, or mesothelioma) and their family members to understand how common BAP1 gene mutations are. Researchers will collect medical history and questionnaires to learn about cancer risks…