Gastric adenocarcinoma and proximal polyposis of the stomach

MONDO:0017790

An autosomal dominant disorder caused by specific pathogenic variants in the APC gene promoter, characterized by proximal gastric polyposis and an increased risk of gastric adenocarcinoma.

Also known as: APC-related gastric adenocarcinoma and proximal polyposis of the stomach, GAPPS, familial fundic gland polyposis with gastric cancer, fundic gland polyposis, polyposis, gastric, polyposis, gastric, Dos Santos and de Magalhaes 1980

2877 clinical trials for this condition and its sub-types, 1 tagged with Gastric adenocarcinoma and proximal polyposis of the stomach itself.

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Where it sits in the disease tree

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↑ Autosomal dominant disease (699) ↑ Hereditary gastric cancer (6) ↑ Polyposis (4)

Including sub-types (2877) Tagged with Gastric adenocarcinoma and proximal polyposis of the stomach (1)

Completed 1

Massive study digs into genetic roots of stomach cancer

Knowledge-focused Completed

This study collected information from 733 people with a personal or family history of hereditary stomach cancer. The goal was to better understand how these cancers develop and what genes are involved. Participants provided medical history, blood samples, and genetic testing. The…

Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused

Last updated Sep 18, 2026 00:00 UTC

Gastric adenocarcinoma and proximal polyposis of the stomach

Where it sits in the disease tree

Massive study digs into genetic roots of stomach cancer