Frontotemporal dementia and/or amyotrophic lateral sclerosis 1

MONDO:0007105

Any frontotemporal dementia with motor neuron disease in which the cause of the disease is a mutation in the C9orf72 gene.

Also known as: ALSFTD, C9ORF72 frontotemporal dementia with motor neuron disease, C9orf72 frontotemporal dementia with motor neuron disease, FTDMND, amyotrophic lateral sclerosis and/or frontotemporal dementia, frontotemporal dementia and/or amyotrophic lateral sclerosis 1, frontotemporal dementia and/or amyotrophic lateral sclerosis type 1, frontotemporal dementia and/or motor neuron disease

26 clinical trials for this condition and its sub-types, 5 tagged with Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 itself.

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Where it sits in the disease tree

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↑ Familial amyotrophic lateral sclerosis (29) ↑ Frontotemporal dementia with motor neuron disease (19) ↑ Frontotemporal dementia and/or amyotrophic lateral sclerosis (5)

Including sub-types (26) Tagged with Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 (5)

Trials to join now! 1 Not yet finished but already full! 3 Terminated 1

Spinal injection drug targets genetic cause of ALS and dementia

Disease control Stopped early

Researchers are testing repeated doses of an experimental drug called WVE-004 in adults who have ALS, frontotemporal dementia, or both, linked to a mutation in the C9orf72 gene. Participants receive the drug by spinal injection every 12 weeks for up to 96 weeks. The study tracks …

Phase 1/2 • Sponsor: Wave Life Sciences USA, Inc. • Aim: Disease control

Last updated Sep 11, 2026 00:00 UTC

Frontotemporal dementia and/or amyotrophic lateral sclerosis 1

Where it sits in the disease tree

Spinal injection drug targets genetic cause of ALS and dementia