FAS-related autoimmune lymphoproliferative syndrome

MONDO:1060194

An autoimmune lymphoproliferative syndrome that results from defective lymphocyte homoestasis, and is caused by variants in the FAS gene. It is characterized by non-malignant lymphoproliferation, autoimmune disease, and lifelong increased risk for both Hodgkin and non-Hodgkin lymphoma.

Also known as: FAS-related autoimmune lymphoproliferative syndrome

86 clinical trials for this condition and its sub-types, 2 tagged with FAS-related autoimmune lymphoproliferative syndrome itself.

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Where it sits in the disease tree

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↑ Autoimmune lymphoproliferative syndrome (12)

Including sub-types (86) Tagged with FAS-related autoimmune lymphoproliferative syndrome (2)

Trials to join now! 1 Not yet finished but already full! 1

New drug aims to calm overactive immune system in rare disorders

Disease control Ongoing

This study tests a drug called leniolisib in 12 people aged 12 to 75 with certain primary immunodeficiency disorders. The goal is to see if the drug is safe and can help control immune system problems. Participants will receive three different doses of the drug, and researchers w…

Phase 2 • Sponsor: Pharming Technologies B.V. • Aim: Disease control

Last updated Jun 27, 2026 09:05 UTC

FAS-related autoimmune lymphoproliferative syndrome

Where it sits in the disease tree

New drug aims to calm overactive immune system in rare disorders