Familial partial lipodystrophy
MONDO:0020088Familial partial lipodystrophy (FPLD) is a group of rare genetic lipodystrophic syndromes characterized, in most cases, by fat loss from the limbs and buttocks, from childhood or early adulthood, and often associated with acanthosis nigricans, insulin resistance, diabetes, hypertriglyceridemia and liver steatosis.
Also known as: FPLD, congenital partial lipodystrophy, genetic partial lipodystrophy, lipodystrophy, familial partial
18 clinical trials for this condition and its sub-types, 13 tagged with Familial partial lipodystrophy itself.
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Browse by category →Sub-types of Familial partial lipodystrophy
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New hope for rare fat disorder: experimental drug mibavademab under safety review
Disease control CompletedThis study tests the safety of switching from the current drug metreleptin to a new experimental drug called mibavademab in people with generalized lipodystrophy, a rare condition where the body cannot properly store fat. Nine participants who have been stable on metreleptin will…
Phase 3 • Sponsor: Regeneron Pharmaceuticals • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC
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Rare fat disorder may quietly fuel hidden inflammation
Knowledge-focused CompletedResearchers are studying whether adults with Dunnigan lipodystrophy, a rare genetic condition that changes how the body stores fat, have higher levels of inflammation than people without it. The trial enrolls 64 non-diabetic adults on Reunion Island, including those with the cond…
Sponsor: Centre Hospitalier Universitaire de la Réunion • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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Researchers investigate Cortisol's role in rare fat disorder
Knowledge-focused CompletedThis study looked at how the body processes cortisol in people with a rare genetic condition called familial partial lipodystrophy type 2 (FPL2). The goal was to see if increased activity of a certain enzyme (11β-HSD1) contributes to the severe metabolic problems seen in this dis…
Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC