Familial medullary thyroid carcinoma

This study tests whether a special PET scan (68Ga-CTR-FAPI) can help surgeons remove all medullary thyroid cancer during the first surgery, aiming for a cure. About 150 newly diagnosed patients will be split into two groups: one gets surgery guided by the new scan, the other gets…

This early-phase study tests a new radioactive drug, 225Ac-ETN029, in 116 adults with advanced DLL3-positive cancers like small cell lung cancer or neuroendocrine tumors. The main goal is to check safety and find the right dose, while also seeing if the drug can shrink tumors. Pa…

This early study tests a personalized mRNA vaccine (mRNA-0523-L001) for people with advanced endocrine tumors like adrenal cancer, medullary thyroid cancer, and pancreatic neuroendocrine tumors who have no standard treatment left. The vaccine is made to target unique mutations in…

This study creates and tests a decision aid for people with medullary thyroid cancer and their caregivers. The tool helps them discuss with their doctors whether to start or stop drugs, join clinical trials, or continue active monitoring. About 120 participants, including patient…

This study will adapt educational materials about medullary thyroid cancer to be more culturally appropriate and easier to understand for Spanish-speaking Hispanic or Latino patients. Researchers will interview 40 participants, including patients and caregivers, to gather feedbac…

This study uses a large registry of 2030 people with medullary thyroid cancer to track how the disease develops and spreads. Researchers will collect medical records, genetic data, and patient surveys to better understand the cancer's natural history. The goal is to improve how a…