Familial Alzheimer disease
MONDO:0100087A degenerative disease of the brain that causes gradual loss of memory, judgment, and the ability to function socially. About 25% of all Alzheimer disease is familial (more than 2 people in a family have AD). When Alzheimer disease begins before 60 or 65 years of age (early-onset AD) about 60% of the cases are familial (also known as Early-onset familial AD). These cases appear to be inherited in an autosomal dominant manner.
Also known as: Alzheimer disease, familial, FAD, GARD:0000632
58 clinical trials for this condition and its sub-types, 13 tagged with Familial Alzheimer disease itself.
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Sub-types of Familial Alzheimer disease
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Early-onset autosomal dominant Alzheimer disease 31 trials · 37 incl. sub-types
14 sub-types
- Alzheimer disease 3 5 trials
- Alzheimer disease type 1 4 trials
- Alzheimer disease 4 3 trials
- Alzheimer disease 10 1 trial
- Alzheimer disease 11 1 trial
- Alzheimer disease 12 1 trial
- Alzheimer disease 13 1 trial
- Alzheimer disease 14 1 trial
- Alzheimer disease 5 1 trial
- Alzheimer disease 6 1 trial
- Alzheimer disease 7 1 trial
- Alzheimer disease 8 1 trial
- Alzheimer disease without neurofibrillary tangles 1 trial
- Alzheimer disease, familial early-onset, with coexisting amyloid and prion pathology 0 trials
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Alzheimer disease 2 11 trials
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Can a new drug stop inherited Alzheimer's in its tracks?
Disease control OngoingThis study tests lecanemab, an antibody that targets amyloid plaques in the brain, in 40 people who carry a gene mutation that causes early-onset Alzheimer's. Participants previously received another anti-amyloid drug and will now receive lecanemab to see if it can fully clear am…
Phase 3 • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Jul 29, 2026 00:00 UTC
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New drug combo aims to halt Alzheimer's in people with genetic mutation
Disease control OngoingThis study tests whether two drugs, E2814 and lecanemab, can slow the progression of Alzheimer's in people who carry a gene mutation that causes the disease. About 197 participants will receive either the drugs or a placebo over 2 to 4 years. Researchers will measure changes in t…
Phase 2/3 • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Jul 29, 2026 00:00 UTC
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Can new drugs delay inherited Alzheimer's? major trial underway
Disease control OngoingThis study tests whether experimental drugs can slow down memory and thinking problems in people who have a gene mutation that causes Alzheimer's disease. About 490 adults aged 18-80 with this genetic risk are taking either a study drug or a placebo. The goal is to see if the dru…
Phase 2/3 • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Jul 29, 2026 00:00 UTC
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Radioactive tracer reveals tau tangles in Alzheimer's brains
Knowledge-focused By invitation onlyThis study tests a new radioactive compound called F 18 T807 that lights up tau tangles in the brain during a PET scan. Researchers want to see if the amount of tau relates to memory and thinking problems in people with a rare, inherited form of Alzheimer's disease. About 130 adu…
Sponsor: Washington University School of Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:04 UTC