Familial acute necrotizing encephalopathy

MONDO:0011953

Familial acute necrotizing encephalopathy or ADANE is a potentially fatal neurological disease characterized by neuropathological lesions principally involving the brainstem, thalamus and putamen.

Also known as: ADANE, encephalopathy, acute, infection-induced, 3, susceptibility to, encephalopathy, acute, infection-induced, susceptibility to, type 3, recurrent acute necrotizing encephalopathy, ANE1, IIAE3, Postinfectious acute necrotizing hemorrhagic encephalopathy, acute necrotizing encephalopathy type 1

2 clinical trials for this condition and its sub-types, 1 tagged with Familial acute necrotizing encephalopathy itself.

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Where it sits in the disease tree

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Part of

↑ Encephalopathy, acute, infection-induced (3) ↑ Mendelian encephalopathy (1)

Including sub-types (2) Tagged with Familial acute necrotizing encephalopathy (1)

Completed 1

Scientists probe gene link to rare brain disease after infections

Knowledge-focused Completed

This study looks at how a specific gene mutation (RANBP2) affects the immune system in people with Acute Necrotizing Encephalopathy type 1 (ANE1), a rare brain condition triggered by infections. Researchers compared blood samples from 35 participants, including patients with the …

Sponsor: University Hospital, Montpellier • Aim: Knowledge-focused

Last updated Jun 27, 2026 09:02 UTC

Familial acute necrotizing encephalopathy

Where it sits in the disease tree

Scientists probe gene link to rare brain disease after infections