Ewing sarcoma/peripheral primitive neuroectodermal tumor
MONDO:0021038A spectrum of malignant tumors, affecting mostly males under age 20, characterized morphologically by the presence of small round cells. Ewing sarcoma and peripheral primitive neuroectodermal tumor represent the ends of a spectrum, with Ewing sarcoma lacking evidence of neural differentiation and the markers that characterize the peripheral primitive neuroectodermal tumor. Ewing sarcoma and peripheral primitive neuroectodermal tumor may share cytogenetic abnormalities, proto-oncogene expression, cell culture and immunohistochemical abnormalities. These tumors may occur in the soft tissues or the bones. Pain and the presence of a mass are the most common clinical symptoms.
Also known as: EFTs, Ewing family of tumors, Ewing family of tumours, Ewing sarcoma family of tumors, Ewing sarcoma family of tumours, Ewing sarcoma/peripheral PNET, Ewing sarcoma/peripheral primitive neuroectodermal tumor, Ewing's family of tumors
1564 clinical trials for this condition and its sub-types, 7 tagged with Ewing sarcoma/peripheral primitive neuroectodermal tumor itself.
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Sub-types of Ewing sarcoma/peripheral primitive neuroectodermal tumor
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Ewing sarcoma 124 trials · 125 incl. sub-types
2 sub-types
- Ewing sarcoma of bone 5 trials
- Extraskeletal Ewing sarcoma 3 trials
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Central nervous system Ewing sarcoma/peripheral primitive neuroectodermal tumor 1 trial · 22 incl. sub-types
4 sub-types
- Esthesioneuroblastoma 9 trials
- Embryonal tumor with multilayered rosettes 8 trials
- Ependymoblastoma 5 trials Sub-types →
- Medulloepithelioma 3 trials
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Peripheral primitive neuroectodermal tumor 7 trials · 8 incl. sub-types
3 sub-types
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Ewing sarcoma/peripheral primitive neuroectodermal tumor of bone 0 trials · 7 incl. sub-types
2 sub-types
- Ewing sarcoma of bone 5 trials
- Peripheral primitive neuroectodermal tumor of bone 3 trials
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Extraskeletal Ewing sarcoma/peripheral primitive neuroectodermal tumor 0 trials · 4 incl. sub-types
2 sub-types
Most studied deeper sub-types
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Targeted drug shows promise for kids with Tough-to-Treat cancers
Disease control OngoingThis study tested the drug ensartinib in 13 children and young adults (ages 1–21) whose cancers had come back or did not respond to treatment and had specific ALK or ROS1 gene changes. The goal was to see if the drug could shrink or stop tumor growth. While the drug targets cance…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jul 12, 2026 00:00 UTC
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New hope for kids with rare cancers: targeted drug larotrectinib tested in small trial
Disease control OngoingThis phase 2 trial is testing the drug larotrectinib in children and young adults (ages 1 to 21) with advanced solid tumors, non-Hodgkin lymphoma, or histiocytic disorders that have a specific genetic change called an NTRK fusion. The cancers have either come back after treatment…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Hope for Tough-to-Treat bone cancer: new combo trial launches
Disease control OngoingThis study tests whether adding the drug abemaciclib to standard chemotherapy can help people with Ewing's sarcoma whose cancer has returned or not responded to treatment. About 46 children and young adults will take part. The goal is to see if the combination slows tumor growth …
Phase 2 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC