Erdheim-Chester disease

MONDO:0018153

Erdheim-Chester disease (ECD), a non-Langerhans form of histiocytosis, is a multisystemic disease characterized by various manifestations such as skeletal involvement with bone pain, exophthalmos, diabetes insipidus, renal impairment and central nervous system (CNS) and/or cardiovascular involvement.

Also known as: Erdheim Chester Disease, Erdheim-Chester disease, lipogranulomatosis, polyostotic sclerosing histiocytosis, ECD, Erdheim Chester disease, lipoid granulomatosis

19 clinical trials for this condition and its sub-types, 14 tagged with Erdheim-Chester disease itself.

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Where it sits in the disease tree

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↑ Syndromic disease (7158) ↑ Non-Langerhans cell histiocytosis (39)

Including sub-types (19) Tagged with Erdheim-Chester disease (14)

Trials to join now! 9 Not yet recruiting 1 Not yet finished but already full! 3 Terminated 1

500 patients to help unlock secrets of rare histiocytosis disorders

Knowledge-focused Not yet recruiting

This study will collect blood, saliva, urine, and stool samples from 500 adults with systemic histiocytosis—a group of rare inflammatory disorders. Researchers aim to identify biomarkers that could improve diagnosis, predict disease progression, and enable less invasive monitorin…

Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused

Last updated Jun 26, 2026 14:07 UTC

Erdheim-Chester disease

Where it sits in the disease tree

500 patients to help unlock secrets of rare histiocytosis disorders