Epilepsy with generalized tonic-clonic seizures
MONDO:0005754A generalized tonic-clonic seizure.
Also known as: EGTCA, epilepsy with generalized tonic-clonic seizures alone, grand Mal epilepsy, tonic-clonic epilepsy
18 clinical trials for this condition and its sub-types, 11 tagged with Epilepsy with generalized tonic-clonic seizures itself.
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New seizure drug shows promise in late-stage trial
Disease control Recruiting nowThis study tests whether XEN1101, taken alongside current seizure medications, can reduce the number of generalized tonic-clonic seizures (convulsions affecting the whole body). About 160 people aged 12 and older with these seizures will receive either XEN1101 or a placebo for se…
Phase 3 • Sponsor: Xenon Pharmaceuticals Inc. • Aim: Disease control
Last updated Aug 12, 2026 00:00 UTC
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Hope for down syndrome: drug may stop Alzheimer's seizures
Prevention Recruiting nowThis study tests if the drug levetiracetam can prevent epileptic seizures in 120 adults over 40 with Down syndrome and Alzheimer's disease. Participants will receive either the drug or a placebo for 96 weeks. The goal is to see if the drug can stop seizures and possibly slow brai…
Phase 3 • Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau • Aim: Prevention
Last updated Jun 27, 2026 08:10 UTC
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Real-world safety of fycompa injection under the microscope for epilepsy patients
Knowledge-focused Recruiting nowThis study tracks the safety of Fycompa injection in people with epilepsy who have partial-onset seizures (age 4 and older) or primary generalized tonic-clonic seizures (age 12 and older). Researchers will record any side effects and measure drug levels in children aged 4 to 12. …
Sponsor: Eisai Co., Ltd. • Aim: Knowledge-focused
Last updated Jul 03, 2026 00:00 UTC