Enthesitis-related juvenile idiopathic arthritis
MONDO:0019437Enthesitis-related juvenile idiopathic arthritis is a subtype of juvenile idiopathic arthritis that is characterized by both arthritis and inflammation of an enthesitis site (the point at which a ligament, tendon, or joint capsule attaches to the bone). Signs and symptoms generally develop in late childhood or early adolescence and include pain, tenderness, and swelling in joints and at the enthesis. The knee and the back of the ankle (at the Achilles tendon) are the most commonly affected parts of the body. The underlying cause of enthesitis-related juvenile idiopathic arthritis is currently unknown (idiopathic). It is very rare for more than one member of a family to have juvenile arthritis; however, research suggests that having a family member with juvenile arthritis or any autoimmune disease may increase the risk of having juvenile arthritis, in general. Treatment usually involves different types of medications to help manage symptoms and/or physical therapy.
Also known as: ERA, enthesitis-related JIA, era, enthesitis related arthritis, juvenile, enthesitis-related arthritis, juvenile enthesitis-related arthritis, juvenile spondylarthropathy
31 clinical trials for this condition and its sub-types, 7 tagged with Enthesitis-related juvenile idiopathic arthritis itself.
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New hope for kids with arthritis: drug trial launches
Disease control Recruiting nowThis study tests a drug called bimekizumab in children aged 2 to 17 with specific types of juvenile arthritis (enthesitis-related arthritis and juvenile psoriatic arthritis). The goal is to see how the drug moves through the body and if it is safe. About 40 children will take par…
Phase 3 • Sponsor: UCB Biopharma SRL • Aim: Disease control
Last updated Jul 19, 2026 00:00 UTC
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Gut bacteria may hold key to why arthritis drugs stop working in kids
Knowledge-focused Recruiting nowThis study is looking at how the gut bacteria (microbiome) change in children with juvenile spondyloarthritis as they receive different treatments. Researchers will collect stool and blood samples from 25 children over several months to see if certain bacteria affect how well the…
Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC