Eisenmenger syndrome

MONDO:0019944

Eisenmenger syndrome (ES) is an form of pulmonary arterial hypertension (PAH) associated with unoperated congenital heart disease and is characterized by congenital heart malformations with reversed or bi-directional shunting through an intra-cardiac or intervascular (usually aorto-pulmonary) communication with the development of PAH.

Also known as: Eisenmenger's syndrome

26 clinical trials for this condition and its sub-types, 5 tagged with Eisenmenger syndrome itself.

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Where it sits in the disease tree

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Part of

↑ Syndromic disease (7158) ↑ Pulmonary arterial hypertension (208)

Including sub-types (26) Tagged with Eisenmenger syndrome (5)

Trials to join now! 2 Not yet recruiting 1 Completed 2

New drug hopes to ease rare Heart-Lung condition

Disease control Not yet recruiting

This study tests a drug called sotatercept in 40 adults with congenital heart disease and Eisenmenger syndrome, a serious condition where blood flow in the lungs is blocked. The drug is given as a shot every three weeks for 24 weeks. The goal is to see if it safely lowers pressur…

Phase 2 • Sponsor: Philipps University Marburg • Aim: Disease control

Last updated Jun 27, 2026 12:00 UTC

Eisenmenger syndrome

Where it sits in the disease tree

New drug hopes to ease rare Heart-Lung condition