Early-onset non-syndromic cataract

MONDO:0011060

Early-onset non-syndromic cataract is a rare, genetic, non-syndromic developmental defect of the eye, with high clinical and genetic heterogeneity, most frequently characterized by bilateral, symmetrical, non-progressive cataracts which present at birth or in early-childhood. Additional ocular manifestations (e.g. anterior segment dysgenesis, colobomas, nystagmus, microcornea, microphthalmia, myopia) may be associated, however other organs/systems are usually not affected.

Also known as: cataract, age-related nuclear, nuclear sclerosis of the lens

2 clinical trials for this condition and its sub-types, 1 tagged with Early-onset non-syndromic cataract itself.

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Where it sits in the disease tree

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Part of

↑ Cataract (305)

Sub-types of Early-onset non-syndromic cataract

Early-onset partial cataract 0 trials · 1 incl. sub-types
5 sub-types
- Early-onset zonular cataract 0 trials · 1 incl. sub-types Sub-types →
- Cataract 30 0 trials
- Cerulean cataract 0 trials Sub-types →
- Early-onset anterior polar cataract 0 trials Sub-types →
- Early-onset posterior subcapsular cataract 0 trials
Cataract 10 multiple types 0 trials
Cataract 11 multiple types 0 trials
Cataract 13 with adult I phenotype 0 trials
Cataract 14 multiple types 0 trials
Cataract 15 multiple types 0 trials
Cataract 17 multiple types 0 trials
Cataract 19 multiple types 0 trials
Cataract 20 multiple types 0 trials
Cataract 21 multiple types 0 trials
Cataract 22 multiple types 0 trials
Cataract 23 0 trials
Cataract 26 multiple types 0 trials
Cataract 31 multiple types 0 trials
Cataract 32 multiple types 0 trials
Cataract 33 0 trials
Cataract 38 0 trials
Cataract 39 multiple types 0 trials
Cataract 40 0 trials
Cataract 42 0 trials
Cataract 43 0 trials
Cataract 44 0 trials
Cataract 45 0 trials
Cataract 46 juvenile-onset 0 trials
Cataract 5 multiple types 0 trials
Cataract 6 multiple types 0 trials
Cataract 8 multiple types 0 trials
Pulverulent cataract 0 trials
Total early-onset cataract 0 trials

Most studied deeper sub-types

Early-onset nuclear cataract (1) Autosomal recessive nonsyndromic congenital nuclear cataract (0) Cataract 16 multiple types (0) Cataract 24 (0) Cataract 25 (0) Cataract 27 (0) Cataract 35 (0) Cataract 37 (0) Cataract 41 (0) Cataract 7 (0) Early-onset lamellar cataract (0) Early-onset posterior polar cataract (0) Early-onset sutural cataract (0)

Including sub-types (2) Tagged with Early-onset non-syndromic cataract (1)

Trials to join now! 1

New study aims to make cataract surgery safer by measuring ultrasound energy

Knowledge-focused Recruiting now

This study compares two different machines used during cataract surgery to see which one uses less ultrasound energy. The researchers will measure the total energy delivered into the eye while removing the cloudy lens. Thirty adults with cataracts in both eyes will take part, wit…

Sponsor: Nicole Fram M.D. • Aim: Knowledge-focused

Last updated Jun 27, 2026 11:02 UTC

Early-onset non-syndromic cataract

Where it sits in the disease tree

Most studied deeper sub-types

New study aims to make cataract surgery safer by measuring ultrasound energy