Drug dependence
MONDO:0005303Drug dependence - replaced the term "drug addiction" and is defined as a state, psychic and sometimes also physical, resulting from the interaction between a living organism and a drug, characterized by behavioral and other responses that always include a compulsion to take the drug on a continuous or periodic basis in order to experience its psychic effects, and sometimes to avoid the discomfort of its absence. Tolerance may or may not be present. A person may be dependent on more than one drug.
Also known as: chemical dependence
1366 clinical trials for this condition and its sub-types, 14 tagged with Drug dependence itself.
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Sub-types of Drug dependence
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Opiate dependence 545 trials
2 sub-types
- Heroin dependence 2 trials
- Morphine dependence 2 trials
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Nicotine dependence 412 trials
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Cannabis dependence 218 trials
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Methamphetamine dependence 63 trials
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Cocaine dependence 51 trials
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Alcohol dependence 44 trials
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Hallucinogen dependence 1 trial
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Alcohol and nicotine codependence 0 trials
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Barbiturate dependence 0 trials
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Phencyclidine abuse 0 trials
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Brazilian study investigates why some HIV patients fail key drug combo
Knowledge-focused OngoingThis study tracks 2,500 people with HIV in Brazil who are taking a common first-line treatment (tenofovir/lamivudine and dolutegravir) to see why some develop drug resistance. Researchers will test blood samples from those whose viral load remains detectable to look for resistanc…
Sponsor: Federal University of São Paulo • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Yale scans brains of synthetic pot users to uncover addiction clues
Knowledge-focused OngoingThis observational study at Yale uses PET brain scans to measure CB1 receptor availability in 15 people who currently use synthetic cannabinoids. Researchers want to see if these receptors are lower in users and how that relates to thinking skills and brain rhythms during withdra…
Sponsor: Yale University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC