Drug dependence
MONDO:0005303Drug dependence - replaced the term "drug addiction" and is defined as a state, psychic and sometimes also physical, resulting from the interaction between a living organism and a drug, characterized by behavioral and other responses that always include a compulsion to take the drug on a continuous or periodic basis in order to experience its psychic effects, and sometimes to avoid the discomfort of its absence. Tolerance may or may not be present. A person may be dependent on more than one drug.
Also known as: chemical dependence
1366 clinical trials for this condition and its sub-types, 14 tagged with Drug dependence itself.
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Sub-types of Drug dependence
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Opiate dependence 545 trials
2 sub-types
- Heroin dependence 2 trials
- Morphine dependence 2 trials
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Nicotine dependence 412 trials
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Cannabis dependence 218 trials
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Methamphetamine dependence 63 trials
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Cocaine dependence 51 trials
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Alcohol dependence 44 trials
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Hallucinogen dependence 1 trial
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Alcohol and nicotine codependence 0 trials
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Barbiturate dependence 0 trials
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Phencyclidine abuse 0 trials
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Could a workout routine boost recovery from addiction?
Disease control Recruiting nowThis study examines whether adding structured high-intensity physical exercise to a 3-month residential treatment program for substance use disorder improves patients' physical health, mental health, and quality of life. Researchers measure changes in oxygen uptake, leg strength,…
Sponsor: St. Olavs Hospital • Aim: Disease control
Last updated Jul 23, 2026 00:00 UTC
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Brain training task may reveal why opioid addiction is so hard to beat
Knowledge-focused Recruiting nowThis study looks at how people with opioid-use disorder learn and make choices compared to those without the disorder. Participants will complete a computer task where shapes are paired with different food odors. The goal is to understand if differences in learning and decision-m…
Sponsor: National Institute on Drug Abuse (NIDA) • Aim: Knowledge-focused
Last updated Sep 13, 2026 00:00 UTC