Digestive system carcinoma
MONDO:0006181A malignant neoplasm that arises from the epithelium of any part of the digestive system. Representative examples include colorectal carcinoma, esophageal carcinoma, and pancreatic carcinoma.
Also known as: carcinoma of digestive system, carcinoma of the gastrointestinal system, digestive system carcinoma, gastrointestinal carcinoma, gastrointestinal carcinoma (disease), gastrointestinal system carcinoma
7486 clinical trials for this condition and its sub-types, 25 tagged with Digestive system carcinoma itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Digestive system carcinoma
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Carcinoma of liver and intrahepatic biliary tract 36 trials · 1,455 incl. sub-types
7 sub-types
- Hepatocellular carcinoma 1,043 trials · 1,088 incl. sub-types Sub-types →
- Bile duct carcinoma 20 trials · 451 incl. sub-types Sub-types →
- Liver neuroendocrine carcinoma 3 trials Sub-types →
- Undifferentiated carcinoma of liver and intrahepatic biliary tract 1 trial
- Biliary cystadenocarcinoma 0 trials
- Liver carcinoma in situ 0 trials Sub-types →
- Squamous cell carcinoma of liver and intrahepatic biliary tract 0 trials Sub-types →
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Colorectal carcinoma 305 trials · 1,166 incl. sub-types
4 sub-types
- Colorectal adenocarcinoma 246 trials · 546 incl. sub-types Sub-types →
- Rectal carcinoma 54 trials · 392 incl. sub-types Sub-types →
- Colon carcinoma 277 trials · 377 incl. sub-types Sub-types →
- Colorectal squamous cell carcinoma 1 trial · 54 incl. sub-types Sub-types →
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Exocrine pancreatic carcinoma 205 trials · 1,033 incl. sub-types
8 sub-types
- Pancreatic adenocarcinoma 493 trials · 926 incl. sub-types Sub-types →
- Squamous cell carcinoma of pancreas 3 trials · 13 incl. sub-types Sub-types →
- Familial pancreatic carcinoma 9 trials
- Pancreatic carcinoma with mixed differentiation 3 trials
- Pancreatic intraductal papillary-mucinous carcinoma 0 trials · 2 incl. sub-types Sub-types →
- Pancreatic mucinous cystadenoma 1 trial
- Pancreatic large cell neuroendocrine carcinoma 0 trials
- Solid pseudopapillary carcinoma of pancreas 0 trials
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Gastric carcinoma 92 trials · 554 incl. sub-types
12 sub-types
- Gastric adenocarcinoma 448 trials · 480 incl. sub-types Sub-types →
- Gastric cardia carcinoma 3 trials · 7 incl. sub-types Sub-types →
- Hereditary gastric cancer 1 trial · 6 incl. sub-types Sub-types →
- Gastric squamous cell carcinoma 4 trials Sub-types →
- Stomach carcinoma in situ 4 trials Sub-types →
- Epstein-Barr virus-associated gastric carcinoma 1 trial
- Gastric body carcinoma 1 trial Sub-types →
- Undifferentiated carcinoma of stomach 1 trial
- Carcinoma of stomach, salivary gland type 0 trials
- Gastric fundus carcinoma 0 trials Sub-types →
- Gastric pylorus carcinoma 0 trials
- Gastric small cell neuroendocrine carcinoma 0 trials
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Gastroesophageal junction adenocarcinoma 506 trials
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Carcinoma of esophagus 75 trials · 504 incl. sub-types
5 sub-types
- Esophageal squamous cell carcinoma 303 trials · 304 incl. sub-types Sub-types →
- Esophageal adenocarcinoma 168 trials · 172 incl. sub-types Sub-types →
- Esophagus carcinoma in situ 13 trials
- Esophageal small cell neuroendocrine carcinoma 2 trials
- Carcinoma of esophagus, salivary gland type 0 trials
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Carcinoma of pharynx 3 trials · 455 incl. sub-types
6 sub-types
- Oropharyngeal carcinoma 99 trials · 242 incl. sub-types Sub-types →
- Nasopharyngeal carcinoma 210 trials · 211 incl. sub-types Sub-types →
- Pharyngeal squamous cell carcinoma 5 trials · 203 incl. sub-types Sub-types →
- Hypopharyngeal carcinoma 35 trials · 86 incl. sub-types Sub-types →
- Pharynx carcinoma in situ 0 trials · 2 incl. sub-types Sub-types →
- Pharyngeal adenoid cystic carcinoma 0 trials
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Oral cavity carcinoma 16 trials · 200 incl. sub-types
9 sub-types
- Oral cavity squamous cell carcinoma 139 trials · 154 incl. sub-types Sub-types →
- Salivary gland carcinoma 26 trials · 36 incl. sub-types Sub-types →
- Oral cavity carcinoma in situ 5 trials Sub-types →
- Tongue carcinoma 4 trials
- Carcinoma of lip 0 trials · 2 incl. sub-types Sub-types →
- Carcinoma of hard palate 1 trial
- Carcinoma of soft palate 1 trial
- Intraoral basal cell carcinoma 0 trials
- Oral cavity mucoepidermoid carcinoma 0 trials Sub-types →
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Small intestine carcinoma 19 trials · 105 incl. sub-types
3 sub-types
- Carcinoma of duodenum 21 trials · 75 incl. sub-types Sub-types →
- Small intestine adenocarcinoma 18 trials · 60 incl. sub-types Sub-types →
- Squamous cell carcinoma of the small intestine 1 trial Sub-types →
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Gallbladder carcinoma 40 trials · 48 incl. sub-types
5 sub-types
- Gallbladder adenocarcinoma 9 trials Sub-types →
- Gall bladder carcinoma in situ 0 trials
- Gallbladder small cell neuroendocrine carcinoma 0 trials
- Gallbladder squamous cell carcinoma 0 trials Sub-types →
- Undifferentiated gallbladder carcinoma 0 trials
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Intestine carcinoma in situ 0 trials · 16 incl. sub-types
2 sub-types
- Rectum carcinoma in situ 1 trial · 13 incl. sub-types Sub-types →
- Colon carcinoma in situ 3 trials Sub-types →
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Pancreatic endocrine carcinoma 12 trials
2 sub-types
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Digestive system mixed adenoneuroendocrine carcinoma 0 trials · 3 incl. sub-types
1 sub-type
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Carcinoma of floor of mouth 1 trial · 2 incl. sub-types
2 sub-types
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Maxillary sinus carcinoma 1 trial · 2 incl. sub-types
3 sub-types
- Maxillary sinus squamous cell carcinoma 1 trial
- Maxillary sinus adenocarcinoma 0 trials
- Maxillary sinus adenoid cystic carcinoma 0 trials
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Ameloblastic carcinoma 0 trials
Most studied deeper sub-types
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Can spreading out radiation beat a single dose for brain tumors?
Disease control OngoingThis Phase III trial tests whether giving radiation in three smaller doses (FSRS) works better than a single large dose (SRS) for cancer that has spread to the brain. About 269 adults with lung, breast, melanoma, kidney, or gastrointestinal cancers will be randomly assigned to on…
Phase 3 • Sponsor: NRG Oncology • Aim: Disease control
Last updated Sep 16, 2026 00:00 UTC
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Experimental drug combo targets Hard-to-Treat GI cancers
Disease control OngoingThis trial tests a new drug called BAY 1895344 (elimusertib) combined with standard chemotherapy (FOLFIRI) in people with advanced or metastatic stomach or colorectal cancer. The goal is to find the safest dose and see if the combination can shrink tumors. Participants receive th…
Phase 1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Aug 23, 2026 00:00 UTC
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Cancer-Fighting T-Cell therapy trial for GI cancers withdrawn before start
Disease control CancelledThis study aimed to test whether a person's own immune cells, modified in a lab to target specific cancer-related mutations (KRAS or TP53), could prevent advanced gastrointestinal cancers from coming back after standard treatment. Participants would have been randomly assigned to…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 26, 2026 15:48 UTC
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AI could speed up cancer testing for digestive tumors
Diagnosis By invitation onlyThis study is developing and testing an AI model that automatically interprets CLDN18.2 protein levels in digestive system tumors. Researchers will use thousands of pathology samples from multiple hospitals to see if the AI can read test results as accurately as human experts. Th…
Sponsor: Nanfang Hospital, Southern Medical University • Aim: Diagnosis
Last updated Jun 27, 2026 09:04 UTC
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Wearable tech could spot Post-Surgery problems early
Symptom relief OngoingThis trial tests whether a home-based telemonitoring program, which tracks symptoms and daily steps using a wearable device and app, can improve recovery and reduce complications within 30 days after abdominal surgery for gastrointestinal, genitourinary, or gynecologic cancers. P…
Sponsor: City of Hope Medical Center • Aim: Symptom relief
Last updated Aug 22, 2026 00:00 UTC
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Can acupuncture replace painkillers after surgery?
Symptom relief OngoingThis study looks at whether acupuncture can help manage pain after open abdominal surgery for colorectal or pancreatic cancer. About 70 patients will either receive acupuncture or standard care. The goal is to see if acupuncture reduces pain and the need for opioid painkillers, h…
Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Jun 27, 2026 13:06 UTC
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Tumor testing could unlock personalized cancer treatments
Knowledge-focused OngoingThis study looks at tumor samples from over 3,000 people with advanced cancers to find specific biomarkers—unique features of each cancer. The goal is to help doctors choose the most promising targeted therapy or clinical trial for each patient. Participants are adults with vario…
Sponsor: University Health Network, Toronto • Aim: Knowledge-focused
Last updated Jul 16, 2026 00:00 UTC