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Diffuse midline glioma, H3 K27M-mutant

MONDO:0957196

A histone mutated tumor that is characterized by the presence of histone H3 K27M mutation located throughout the midline structures of the central nervous system.

3072 clinical trials for this condition and its sub-types, 31 tagged with Diffuse midline glioma, H3 K27M-mutant itself.

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Where it sits in the disease tree

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↑ Diffuse midline glioma, H3 K27-altered (39)

Including sub-types (3072) Tagged with Diffuse midline glioma, H3 K27M-mutant (31)

Trials to join now! 22 Not yet recruiting 2 Not yet finished but already full! 6 Terminated 1

Engineered t cells take on deadly childhood brain cancer

Disease control Stopped early

This early-phase trial tests a new treatment for children and young adults with a rare, aggressive brain tumor called H3.3K27M-mutated diffuse midline glioma. The treatment involves taking a patient's own immune cells (T cells), genetically modifying them in the lab to recognize …

Phase 1 • Sponsor: University of California, San Francisco • Aim: Disease control

Last updated Jul 15, 2026 00:00 UTC