Diffuse midline glioma, H3 K27M-mutant
MONDO:0957196A histone mutated tumor that is characterized by the presence of histone H3 K27M mutation located throughout the midline structures of the central nervous system.
3082 clinical trials for this condition and its sub-types, 31 tagged with Diffuse midline glioma, H3 K27M-mutant itself.
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Can sound waves open the brain to Cancer-Fighting cells?
Cure Not yet recruitingThis phase 1 trial tests a new approach for diffuse midline glioma (DMG), an aggressive brain tumor with a poor prognosis. The treatment combines focused ultrasound to temporarily open the blood-brain barrier with an infusion of immune cells engineered to attack the tumor. The st…
Phase 1 • Sponsor: Children's National Research Institute • Aim: Cure
Last updated Sep 02, 2026 00:00 UTC
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New hope for young brain cancer patients: enzyme therapy targets tumors
Disease control Not yet recruitingThis study tests a drug called ADI-PEG 20, which breaks down an amino acid that some brain tumors need to grow. It is given alongside standard radiation and chemotherapy to children, adolescents, and young adults with newly diagnosed high-grade glioma. The goal is to see if this …
Phase 1/2 • Sponsor: Sabine Mueller, MD, PhD • Aim: Disease control
Last updated Sep 17, 2026 00:00 UTC