Diffuse midline glioma, H3 K27-altered

MONDO:1060171

A diffuse midline glioma characterized by H3 K27 alteration and usually either a histone H3 K27M mutation, an EGFR mutation, or aberrant overexpression of EZHIP. The prognosis is poor.

Also known as: DMG, H3 K27-altered

3088 clinical trials for this condition and its sub-types, 11 tagged with Diffuse midline glioma, H3 K27-altered itself.

Follow this condition to get notified about new trials

Where it sits in the disease tree

Browse by category →

Part of

↑ Diffuse intrinsic pontine glioma (95)

Sub-types of Diffuse midline glioma, H3 K27-altered

Diffuse midline glioma, H3 K27M-mutant 31 trials

Including sub-types (3088) Tagged with Diffuse midline glioma, H3 K27-altered (11)

Trials to join now! 8 Not yet recruiting 1 Completed 2

Sound waves could open Brain's barrier to fight deadly tumor

Disease control Not yet recruiting

This study tests a new way to treat a rare and aggressive brain tumor called diffuse midline glioma (DMG) in the brainstem. The approach uses MRI-guided focused ultrasound to temporarily open the blood-brain barrier, allowing more of the chemotherapy drug temozolomide to reach th…

Phase 1/2 • Sponsor: UMC Utrecht • Aim: Disease control

Last updated Jun 27, 2026 12:28 UTC

Diffuse midline glioma, H3 K27-altered

Where it sits in the disease tree

Sound waves could open Brain's barrier to fight deadly tumor