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Diffuse low-grade glioma, MAPK pathway–altered
MONDO:0859614A low grade glioma that is characterized by a gene alteration that results in a MAPK pathway abnormality, with morphological features of astrocytoma or oligodendroglioma.
1451 clinical trials for this condition and its sub-types, 3 tagged with Diffuse low-grade glioma, MAPK pathway–altered itself.
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New drug cocktail shows promise for tough childhood brain cancers
Disease control OngoingThis trial is testing whether adding hydroxychloroquine to two targeted cancer drugs (dabrafenib and trametinib) can help children and young adults with certain brain tumors that have come back or not responded to treatment. The study includes patients with specific genetic chang…
Phase 1/2 • Sponsor: Pediatric Brain Tumor Consortium • Aim: Disease control
Last updated Sep 13, 2026 00:00 UTC
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New hope for kids with rare brain tumors? early trial launches in japan
Disease control OngoingThis early-phase study is testing the safety and how the body handles a drug called tovorafenib in Japanese children, teens, and young adults with a type of brain tumor (low-grade glioma) that has a specific genetic change (BRAF alteration) and has come back or is growing. Six pa…
Phase 1 • Sponsor: Ipsen • Aim: Disease control
Last updated Sep 05, 2026 00:00 UTC