Diffuse large B-cell lymphoma of the central nervous system
MONDO:0017596A diffuse large B-cell lymphoma arising from the central nervous system.
Also known as: CNS DLBCL, DLBCL of the CNS, central nervous system diffuse large B-cell lymphoma, diffuse large B-cell lymphoma of central nervous system, primary DLBCL of the CNS, primary diffuse large B-cell lymphoma of the central nervous system
3230 clinical trials for this condition and its sub-types, 21 tagged with Diffuse large B-cell lymphoma of the central nervous system itself.
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Experimental pill plus chemo takes aim at Hard-to-Treat brain lymphoma
Disease control Not yet recruitingThis early-phase trial tests a new oral drug called golcadomide combined with standard chemotherapy drugs (pemetrexed, rituximab, and dexamethasone) in 18 adults with large B-cell lymphoma that has spread to the brain or central nervous system and has either returned or is not re…
Phase 1 • Sponsor: Allison Winter • Aim: Disease control
Last updated Aug 23, 2026 00:00 UTC
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New hope for brain cancer: targeted drug combo shows promise
Disease control Not yet recruitingThis phase 2 trial tests a combination of zanubrutinib (a targeted drug) plus chemotherapy for people newly diagnosed with central nervous system lymphoma. Nineteen participants will receive the treatment, with an extra drug for those with a specific gene mutation. The goal is to…
Phase 2 • Sponsor: Ruijin Hospital • Aim: Disease control
Last updated Jun 27, 2026 09:05 UTC
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New combo therapy aims to tackle rare brain cancer
Disease control Not yet recruitingThis study tests a new approach for primary central nervous system lymphoma (PCNSL), a rare brain cancer. It combines CAR-T cell therapy, a stem cell transplant, and two drugs (orelabrutinib and sintilimab) to see if the mix is safe and effective. The trial plans to enroll 30 adu…
Sponsor: Zhengzhou University • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
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Scientists map the genetic secrets of a rare brain cancer to pave the way for smarter treatments
Knowledge-focused Not yet recruitingThis study examines tumor samples from 100 people diagnosed with primary central nervous system diffuse large B-cell lymphoma (PCNS-DLBCL), a rare cancer that starts in the brain or spine. Researchers will use advanced genetic and molecular techniques to identify patterns in the …
Sponsor: International Extranodal Lymphoma Study Group (IELSG) • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:01 UTC