Developmental and/or epileptic encephalopathy with spike-wave activation in sleep
MONDO:0800501A rare epileptic encephalopathy of childhood characterized by seizures, an electroencephalographic (EEG) pattern of electrical status epilepticus in sleep (ESES) and neurocognitive regression in at least 2 domains of development. This syndrome encompasses the previous syndromes epileptic encephalopathy with continuous spike-wave in sleep and atypical childhood epilepsy with centrotemporal spikes (also previously known as pseudo-Lennox syndrome and atypical benign partial epilepsy).
Also known as: CSWS, CSWSS syndrome, DEE-SWAS, EE-SWAS, EESWAS, ESES with language regression, LK syndrome, LKS
16 clinical trials for this condition and its sub-types, 8 tagged with Developmental and/or epileptic encephalopathy with spike-wave activation in sleep itself.
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Sub-types of Developmental and/or epileptic encephalopathy with spike-wave activation in sleep
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Brain seizures after cardiac arrest: can early treatment save lives?
Disease control Recruiting nowThis trial studies whether giving anti-seizure medication to comatose patients who have brain seizure activity after cardiac arrest can improve their recovery. Participants are randomly assigned to receive either standard care alone or standard care plus a stepwise anti-seizure t…
Sponsor: University of Twente • Aim: Disease control
Last updated Jul 09, 2026 00:00 UTC
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Could a zapping cap tame epilepsy seizures?
Disease control Recruiting nowThis pilot study tests whether a mild electrical current applied to the scalp (called tDCS) can reduce seizures in people with epilepsy. Thirty adults with hard-to-control epilepsy will use a head device for 30 minutes daily over two months. Researchers will track seizure counts …
Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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Could nighttime brain activity steal memories in kids with epilepsy?
Knowledge-focused Recruiting nowThis study looks at how sleep affects memory in children with certain types of epilepsy. Researchers will test memory before and after sleep in 95 children, comparing those with mild epilepsy, severe epilepsy, and no epilepsy. The goal is to see if epileptic brain activity during…
Sponsor: University Hospital, Strasbourg, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:02 UTC