Developmental and epileptic encephalopathy
MONDO:0100620An epilepsy associated with developmental impairment that may be due to either the underlying etiology or the superimposed epileptic activity, or both.
Also known as: DEE, developmental and epileptic encephalopathy, infantile spasm
106 clinical trials for this condition and its sub-types, 29 tagged with Developmental and epileptic encephalopathy itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Developmental and epileptic encephalopathy
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Genetic developmental and epileptic encephalopathy 2 trials · 83 incl. sub-types
105 sub-types
- Dravet syndrome 39 trials
- Lennox-Gastaut syndrome 26 trials · 27 incl. sub-types Sub-types →
- Developmental and epileptic encephalopathy, 2 10 trials
- Developmental and epileptic encephalopathy, 4 6 trials
- Neonatal-onset developmental and epileptic encephalopathy 0 trials · 5 incl. sub-types Sub-types →
- Developmental and epileptic encephalopathy, 11 4 trials
- Developmental and epileptic encephalopathy, 14 3 trials
- Developmental and epileptic encephalopathy, 1 2 trials
- Developmental and epileptic encephalopathy, 17 2 trials
- Developmental and epileptic encephalopathy 114 1 trial
- Developmental and epileptic encephalopathy, 35 1 trial
- Developmental and epileptic encephalopathy, 7 1 trial
- Non-neonatal early infantile epileptic encephalopathy 1 trial
- DNM1-encephalopathy and neurodevelopmental disorder 0 trials Sub-types →
- TMEM63B-related developmental and epileptic encephalopathy with anemia 0 trials
- Developmental and epileptic encephalopathy 100 0 trials
- Developmental and epileptic encephalopathy 101 0 trials
- Developmental and epileptic encephalopathy 102 0 trials
- Developmental and epileptic encephalopathy 103 0 trials
- Developmental and epileptic encephalopathy 104 0 trials
- Developmental and epileptic encephalopathy 105 with hypopituitarism 0 trials
- Developmental and epileptic encephalopathy 106 0 trials
- Developmental and epileptic encephalopathy 107 0 trials
- Developmental and epileptic encephalopathy 108 0 trials
- Developmental and epileptic encephalopathy 109 0 trials
- Developmental and epileptic encephalopathy 110 0 trials
- Developmental and epileptic encephalopathy 111 0 trials
- Developmental and epileptic encephalopathy 112 0 trials
- Developmental and epileptic encephalopathy 113 0 trials
- Developmental and epileptic encephalopathy 115 0 trials
- Developmental and epileptic encephalopathy 116 0 trials
- Developmental and epileptic encephalopathy 118 0 trials
- Developmental and epileptic encephalopathy 119 0 trials
- Developmental and epileptic encephalopathy 120 0 trials
- Developmental and epileptic encephalopathy 121 0 trials
- Developmental and epileptic encephalopathy 6B 0 trials
- Developmental and epileptic encephalopathy 89 0 trials
- Developmental and epileptic encephalopathy 91 0 trials
- Developmental and epileptic encephalopathy 92 0 trials
- Developmental and epileptic encephalopathy 93 0 trials
- Developmental and epileptic encephalopathy 96 0 trials
- Developmental and epileptic encephalopathy 97 0 trials
- Developmental and epileptic encephalopathy 98 0 trials
- Developmental and epileptic encephalopathy 99 0 trials
- Developmental and epileptic encephalopathy, 15 0 trials
- Developmental and epileptic encephalopathy, 18 0 trials
- Developmental and epileptic encephalopathy, 19 0 trials
- Developmental and epileptic encephalopathy, 23 0 trials
- Developmental and epileptic encephalopathy, 27 0 trials
- Developmental and epileptic encephalopathy, 3 0 trials
- Developmental and epileptic encephalopathy, 30 0 trials
- Developmental and epileptic encephalopathy, 36 0 trials
- Developmental and epileptic encephalopathy, 37 0 trials
- Developmental and epileptic encephalopathy, 38 0 trials
- Developmental and epileptic encephalopathy, 40 0 trials
- Developmental and epileptic encephalopathy, 48 0 trials
- Developmental and epileptic encephalopathy, 49 0 trials
- Developmental and epileptic encephalopathy, 5 0 trials
- Developmental and epileptic encephalopathy, 50 0 trials
- Developmental and epileptic encephalopathy, 51 0 trials
- Developmental and epileptic encephalopathy, 52 0 trials
- Developmental and epileptic encephalopathy, 53 0 trials
- Developmental and epileptic encephalopathy, 54 0 trials
- Developmental and epileptic encephalopathy, 55 0 trials
- Developmental and epileptic encephalopathy, 56 0 trials
- Developmental and epileptic encephalopathy, 57 0 trials
- Developmental and epileptic encephalopathy, 58 0 trials
- Developmental and epileptic encephalopathy, 59 0 trials
- Developmental and epileptic encephalopathy, 60 0 trials
- Developmental and epileptic encephalopathy, 61 0 trials
- Developmental and epileptic encephalopathy, 62 0 trials
- Developmental and epileptic encephalopathy, 63 0 trials
- Developmental and epileptic encephalopathy, 64 0 trials
- Developmental and epileptic encephalopathy, 65 0 trials
- Developmental and epileptic encephalopathy, 66 0 trials
- Developmental and epileptic encephalopathy, 67 0 trials
- Developmental and epileptic encephalopathy, 68 0 trials
- Developmental and epileptic encephalopathy, 69 0 trials
- Developmental and epileptic encephalopathy, 6A 0 trials
- Developmental and epileptic encephalopathy, 70 0 trials
- Developmental and epileptic encephalopathy, 71 0 trials
- Developmental and epileptic encephalopathy, 72 0 trials
- Developmental and epileptic encephalopathy, 73 0 trials
- Developmental and epileptic encephalopathy, 74 0 trials
- Developmental and epileptic encephalopathy, 75 0 trials
- Developmental and epileptic encephalopathy, 76 0 trials
- Developmental and epileptic encephalopathy, 77 0 trials
- Developmental and epileptic encephalopathy, 78 0 trials
- Developmental and epileptic encephalopathy, 79 0 trials
- Developmental and epileptic encephalopathy, 8 0 trials
- Developmental and epileptic encephalopathy, 80 0 trials
- Developmental and epileptic encephalopathy, 81 0 trials
- Developmental and epileptic encephalopathy, 82 0 trials
- Developmental and epileptic encephalopathy, 83 0 trials
- Developmental and epileptic encephalopathy, 84 0 trials
- Developmental and epileptic encephalopathy, 85, with or without midline brain defects 0 trials
- Developmental and epileptic encephalopathy, 86 0 trials
- Developmental and epileptic encephalopathy, 87 0 trials
- Developmental and epileptic encephalopathy, 88 0 trials
- Developmental and epileptic encephalopathy, 9 0 trials
- Developmental and epileptic encephalopathy, 90 0 trials
- Hemiplegic migraine-developmental and epileptic encephalopathy spectrum 0 trials
- Microcephaly, seizures, and developmental delay 0 trials
- Multiple congenital anomalies-hypotonia-seizures syndrome 2 0 trials
- Neonatal-onset encephalopathy with rigidity and seizures 0 trials
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Early-infantile DEE 2 trials
3 sub-types
Most studied deeper sub-types
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New hope for kids with rare epilepsy: first human trial launches
Disease control Recruiting nowThis study tests a new medicine (S230815) for children aged 2-12 with a rare, severe epilepsy caused by changes in the KCNT1 gene. The goal is to see if the drug is safe and can help control seizures. About 20 children will take part, receiving the drug through a spinal injection…
Phase 1/2 • Sponsor: Institut de Recherches Internationales Servier • Aim: Disease control
Last updated Aug 13, 2026 00:00 UTC
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New hope for babies with rare seizure disorder: drug trial targets SCN2A gene
Disease control Recruiting nowThis study tests a medicine called elsunersen in 40 children with a rare, severe form of epilepsy caused by changes in the SCN2A gene. The goal is to see if the drug can safely reduce how often seizures happen over 24 weeks. Children must have started having seizures before 3 mon…
Phase 3 • Sponsor: Praxis Precision Medicines • Aim: Disease control
Last updated Aug 05, 2026 00:00 UTC
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Could a Weight-Loss drug stop seizures in babies?
Disease control Recruiting nowThis study tests the drug fenfluramine in 10 children aged 12 to 36 months whose infantile spasms did not get better with standard treatments. The children take fenfluramine for 21 days, and doctors check brain waves and seizure diaries to see if the spasms stop. If it helps, the…
Phase 2 • Sponsor: Children's Hospital of Orange County • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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High-Fat diet may stop infant seizures before they start
Prevention Recruiting nowThis early-phase study tests whether a ketogenic (high-fat) diet can prevent epileptic spasms in infants with genetic epilepsy. Ten babies under 9 months old will receive the diet and be monitored with regular EEGs. The goal is to see if this approach is safe and feasible, potent…
Phase 1 • Sponsor: Heather Olson • Aim: Prevention
Last updated Jul 08, 2026 00:00 UTC
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Scientists launch major study to unravel mysterious metabolism disorders
Knowledge-focused Recruiting nowThis study aims to learn more about rare disorders that affect how the body processes chemicals called pyrimidines and purines. These disorders can cause problems in the brain, blood, kidneys, and immune system, ranging from mild to life-threatening. Researchers will compare test…
Sponsor: National Human Genome Research Institute (NHGRI) • Aim: Knowledge-focused
Last updated Aug 21, 2026 00:00 UTC
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New study aims to map rare childhood brain disorder
Knowledge-focused Recruiting nowThis study will follow 60 children with SLC6A1-NDD, a rare genetic condition causing seizures, developmental delays, and autism. Researchers will track symptoms like seizure frequency and development over time to better understand the disease. The goal is to gather information th…
Sponsor: UCB Biopharma SRL • Aim: Knowledge-focused
Last updated Aug 02, 2026 00:00 UTC
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Gene testing may personalize seizure care for infants
Knowledge-focused Recruiting nowThis study is collecting genetic information from 2,000 infants in China who had seizures before their first birthday. Researchers aim to find gene changes linked to seizures and see if personalized treatments can help control them better. The goal is to understand the genetic ca…
Sponsor: Children's Hospital of Fudan University • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
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Researchers launch major study to understand rare childhood epilepsy disorders
Knowledge-focused Recruiting nowThis study tracks children and adults with genetic developmental and epileptic encephalopathy (DEE) over time. It does not test any treatment but collects information on development, seizures, and quality of life through in-person visits, virtual visits, or online surveys. The go…
Sponsor: Weill Medical College of Cornell University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC
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Massive genetic study aims to unlock Epilepsy's secrets
Knowledge-focused Recruiting nowResearchers at Boston Children's Hospital are recruiting 5,000 people with epilepsy to study their genes. By comparing DNA from patients and their parents, they hope to find genetic changes linked to epilepsy. This study does not test a new drug or treatment, but aims to better u…
Sponsor: Boston Children's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:09 UTC
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New registry aims to unlock secrets of rare baby epilepsy
Knowledge-focused Recruiting nowThis study is creating a registry of 200 patients with a rare, severe epilepsy that starts in the first month of life, often linked to a mutation in the KCNQ2 gene. Researchers will collect data on seizures, brain activity, development, and long-term outcomes through questionnair…
Sponsor: Assistance Publique Hopitaux De Marseille • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC