Desmoplastic melanoma

MONDO:0044785

A melanoma of the skin characterized by a proliferation of atypical spindled melanocytes in the dermis, in a background of abundant collagen. It usually presents as an amelanotic raised nodular lesion.

Also known as: desmoplastic cutaneous (skin) melanoma, desmoplastic melanoma

2759 clinical trials for this condition and its sub-types, 1 tagged with Desmoplastic melanoma itself.

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Where it sits in the disease tree

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↑ Cutaneous melanoma (285) ↑ Malignant spindle cell neoplasm (40) ↑ Spindle cell melanoma (1)

Including sub-types (2759) Tagged with Desmoplastic melanoma (1)

Not yet finished but already full! 1

Immunotherapy shows promise against rare skin cancer

Disease control Ongoing

This phase II trial tests pembrolizumab, an immunotherapy drug, in 57 patients with desmoplastic melanoma, a rare skin cancer. The drug helps the immune system attack cancer cells. The study includes patients whose tumors can be surgically removed (cohort A) and those whose canno…

Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control

Last updated Jul 09, 2026 00:00 UTC

Desmoplastic melanoma

Where it sits in the disease tree

Immunotherapy shows promise against rare skin cancer