Dentatorubral-pallidoluysian atrophy

MONDO:0007435

Dentatorubral pallidoluysian atrophy (DRPLA) is a rare subtype of type I autosomal dominant cerebellar ataxia (ADCA type I). It is characterized by involuntary movements, ataxia, epilepsy, mental disorders, cognitive decline and prominent anticipation.

Also known as: DRPLA, Dentatorubropallidoluysian atrophy, Naito-Oyanagi disease, dentatorubral-pallidoluysian atrophy, haw River syndrome, NOD, Naito Oyanagi disease, ataxia, chorea, seizures, and dementia

23 clinical trials for this condition and its sub-types, 4 tagged with Dentatorubral-pallidoluysian atrophy itself.

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Where it sits in the disease tree

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Part of

↑ Huntington disease-like syndrome (17) ↑ Autosomal dominant cerebellar ataxia type IV (8)

Including sub-types (23) Tagged with Dentatorubral-pallidoluysian atrophy (4)

Trials to join now! 1 Not yet finished but already full! 3

New global registry aims to unlock secrets of rare brain disease DRPLA

Knowledge-focused Recruiting now

This study creates a worldwide database for people with DRPLA, a rare genetic brain disorder. Participants or their caregivers fill out questionnaires about symptoms, daily life, and disease impact. The goal is to gather information to help researchers better understand DRPLA and…

Sponsor: CureDRPLA • Aim: Knowledge-focused

Last updated Jun 27, 2026 11:02 UTC

Dentatorubral-pallidoluysian atrophy

Where it sits in the disease tree

New global registry aims to unlock secrets of rare brain disease DRPLA