Cushing disease due to pituitary adenoma
MONDO:0009050A form of adrenocorticotropic hormone (ACTH)-dependent Cushing syndrome, an endogenous Cushing syndrome (CS), characterized by chronic over-secretion of adrenocorticotropic hormone (ACTH) due to a pituitary corticotroph adenoma.
Also known as: ACTH producing pituitary adenoma, Cushing disease, Cushing disease, pituitary, Cushing's disease, PITA4, corticotroph pituitary adenoma, pituitary adenoma 4, ACTH-secreting, pituitary adenoma 4, ACTH-secreting, somatic
1545 clinical trials for this condition and its sub-types, 23 tagged with Cushing disease due to pituitary adenoma itself.
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New pill could tame hormone disorder Cushing's syndrome
Disease control OngoingThis early-stage study tests an experimental pill called CRN04894 in 18 adults with Cushing's syndrome caused by too much ACTH hormone. The drug works by blocking the receptor that ACTH acts on, aiming to lower cortisol levels and control the disease. The main goals are to check …
Phase 1/2 • Sponsor: Crinetics Pharmaceuticals Inc. • Aim: Disease control
Last updated Aug 21, 2026 00:00 UTC
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New drug combo aims to tame Cushing's disease with fewer side effects
Disease control By invitation onlyThis study tests whether adding cabergoline to osilodrostat works better than osilodrostat alone for controlling Cushing's disease. About 50 adults with active Cushing's disease will receive either the combination or the single drug. The goal is to see if the combo can lower cort…
Phase 4 • Sponsor: University of Basrah • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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New scan could replace invasive test for Cushing's disease diagnosis
Diagnosis By invitation onlyThis study compares a new, non-invasive PET-MRI scan to the standard invasive test (IPSS) for finding pituitary tumors in people with Cushing's disease. About 43 adults with confirmed Cushing's will get both tests to see which is more accurate. The goal is to make diagnosis safer…
Sponsor: University Hospital, Basel, Switzerland • Aim: Diagnosis
Last updated Jul 08, 2026 00:00 UTC
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Saliva test could replace complex procedures for Cushing's diagnosis
Diagnosis OngoingThis study aims to see if a simple, inexpensive saliva test can accurately diagnose Cushing's syndrome, a condition where the body makes too much cortisol. Researchers will compare two automated saliva test methods in 380 adults who are already being checked for the condition. Th…
Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Diagnosis
Last updated Jun 27, 2026 07:58 UTC
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Cushing's disease study in western france withdrawn before starting
Knowledge-focused CancelledThis study was designed to look back at the health of people with Cushing's disease in Western France between 1990 and 2015. The goal was to find out how many patients went into remission and how many had their disease come back after their first surgery. However, the study was w…
Sponsor: University Hospital, Brest • Aim: Knowledge-focused
Last updated Jun 28, 2026 00:00 UTC