Cryptococcal meningitis
MONDO:0005723Meningeal inflammation produced by cryptococcus neoformans, an encapsulated yeast that tends to infect individuals with acquired immunodeficiency syndrome and other immunocompromised states. The organism enters the body through the respiratory tract, but symptomatic infections are usually limited to the lungs and nervous system. The organism may also produce parenchymal brain lesions (torulomas). Clinically, the course is subacute and may feature headache; nausea; photophobia; focal neurologic deficits; seizures; cranial neuropathies; and hydrocephalus. (From Adams et al., Principles of Neurology, 6th ed, pp721-2)
Also known as: Cryptococcus neoformans caused infectious meningitis, Cryptococcus neoformans infectious meningitis
15 clinical trials for this condition and its sub-types, 7 tagged with Cryptococcal meningitis itself.
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New hope against a deadly brain infection: large trial tests safer antifungals
Disease control Recruiting nowThis large platform trial is testing new antifungal drug combinations for cryptococcal meningitis, a severe brain infection that is fatal without treatment and common in people with HIV. The study will enroll 2,000 participants across multiple sites to compare a newer oral drug, …
Phase 2/3 • Sponsor: David Boulware • Aim: Disease control
Last updated Jul 29, 2026 00:00 UTC
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Could a single shot stop deadly meningitis in HIV patients?
Disease control Recruiting nowThis study tests whether adding one dose of a stronger antifungal drug (liposomal amphotericin) to the standard treatment (fluconazole) can prevent cryptococcal meningitis in HIV-positive adults who test positive for the fungus but have no symptoms. About 356 participants in Ugan…
Phase 2/3 • Sponsor: Makerere University • Aim: Disease control
Last updated Jun 27, 2026 12:25 UTC
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Why do healthy people get this fungal infection? new study aims to find out
Knowledge-focused Recruiting nowThis study looks at 800 healthy adults who have cryptococcosis, a fungal infection that usually only harms people with weak immune systems. Researchers want to learn why these otherwise healthy people get sick, how their immune system responds, and how the disease progresses over…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Sep 12, 2026 00:00 UTC
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Scientists launch Long-Term study to unravel mysterious immune condition
Knowledge-focused Recruiting nowThis study follows 950 people with idiopathic CD4+ lymphocytopenia (ICL), a rare condition where low CD4+ white blood cells raise infection risk. Researchers will track participants for up to 10 years, collecting medical history, blood samples, and infection data. The goal is to …
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Sep 02, 2026 00:00 UTC